IntOGen - IDH2 gene cancer mutations

IDH2 is detected as a mutational cancer driver

IDH2 reports

Methods
Mutation distribution

Gene details

IDH2
Ensembl ID ENSG00000182054 Transcript ID ENST00000330062 Protein ID ENSP00000331897
Cancer types where is driver 5 Cohorts where is driver 8 Mutated samples 78 Mutations 178
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence