HOXD12 has not been detected as a mutational cancer driver

Ensembl id ENSG00000170178
Mutated samples
Coding Sequence 25 (0.4%)
Protein Affecting 17 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HOXD12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 4 3 0.80
Lung adenocarcinoma No 4 2 0.51
Lung squamous cell carcinoma No 3 2 1.15
Thyroid carcinoma No 2 2 0.62
Stomach adenocarcinoma No 3 2 1.24
Breast carcinoma No 1 1 0.09
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Cutaneous melanoma No 2 1 0.27
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Prostate adenocarcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence