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HDAC3 mutations in 4 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma

HDAC3
Ensembl id ENSG00000171720
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 22 (0.3%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HDAC3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 16 8 2.17
Uterine corpus endometrioid carcinoma Yes 3 2 0.87
Serous ovarian adenocarcinoma Yes 3 2 0.63
Stomach adenocarcinoma Yes 3 2 1.24
Breast carcinoma No 3 2 0.17
Head and neck squamous cell carcinoma No 5 2 0.53
Acute myeloid leukemia No 1 1 0.51
Lung squamous cell carcinoma No 4 1 0.57
Small cell lung carcinoma No 2 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Prostate adenocarcinoma No 1 0 0.00
Lung adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 1 0 0.00
Bladder carcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Lower grade glioma No 1 0 0.00
Esophageal carcinoma No 3 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence