Top
HAPLN1 has not been detected as a mutational cancer driver

HAPLN1
Ensembl id ENSG00000145681
Mutated samples
Coding Sequence 70 (1.0%)
Protein Affecting 45 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HAPLN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 14 3.79
Lung adenocarcinoma No 6 6 1.53
Lung squamous cell carcinoma No 6 5 2.87
Colorectal adenocarcinoma No 7 4 1.75
Uterine corpus endometrioid carcinoma No 2 2 0.87
Chronic lymphocytic leukemia No 4 2 0.69
Stomach adenocarcinoma No 2 2 1.24
Esophageal carcinoma No 3 2 1.37
Hepatocarcinoma No 6 1 1.11
Breast carcinoma No 1 1 0.09
Renal clear cell carcinoma No 3 1 0.24
Thyroid carcinoma No 1 1 0.31
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 2 1 0.27
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence