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GPR158 has not been detected as a mutational cancer driver

GPR158
Ensembl id ENSG00000151025
Mutated samples
Coding Sequence 195 (2.9%)
Protein Affecting 134 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GPR158 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 55 35 9.49
Lung adenocarcinoma No 29 23 5.88
Lung squamous cell carcinoma No 18 14 8.05
Head and neck squamous cell carcinoma No 13 12 3.20
Breast carcinoma No 9 7 0.61
Stomach adenocarcinoma No 9 7 4.35
Uterine corpus endometrioid carcinoma No 8 5 2.17
Esophageal carcinoma No 7 5 3.42
Colorectal adenocarcinoma No 5 4 1.75
Hepatocarcinoma No 6 3 3.33
Bladder carcinoma No 3 3 3.06
Renal clear cell carcinoma No 3 3 0.72
Small cell lung carcinoma No 5 3 4.35
Prostate adenocarcinoma No 2 2 0.82
Chronic lymphocytic leukemia No 11 2 0.69
Serous ovarian adenocarcinoma No 4 2 0.63
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Glioblastoma multiforme No 1 1 0.26
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence