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FBN2 has not been detected as a mutational cancer driver

FBN2
Ensembl id ENSG00000138829
Mutated samples
Coding Sequence 292 (4.3%)
Protein Affecting 228 (3.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FBN2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 55 45 12.20
Lung adenocarcinoma No 41 38 9.72
Lung squamous cell carcinoma No 24 20 11.49
Head and neck squamous cell carcinoma No 21 17 4.53
Renal clear cell carcinoma No 14 12 2.88
Stomach adenocarcinoma No 18 12 7.45
Uterine corpus endometrioid carcinoma No 13 11 4.78
Colorectal adenocarcinoma No 11 9 3.93
Esophageal carcinoma No 11 9 6.16
Glioblastoma multiforme No 11 8 2.11
Breast carcinoma No 8 7 0.61
Serous ovarian adenocarcinoma No 9 6 1.90
Hepatocarcinoma No 8 5 5.56
Bladder carcinoma No 5 5 5.10
Neuroblastoma No 6 5 2.38
Small cell lung carcinoma No 6 5 7.25
Pancreas adenocarcinoma No 4 3 1.40
Prostate adenocarcinoma No 3 2 0.82
Thyroid carcinoma No 3 2 0.62
Chronic lymphocytic leukemia No 11 2 0.69
Multiple myeloma No 2 2 2.90
Lower grade glioma No 2 2 1.18
Medulloblastoma No 1 1 0.48
Acute myeloid leukemia No 1 0 0.00
Non small cell lung carcinoma No 3 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence