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FAT1 is detected as a mutational cancer driver in 3 cancer types: Lung adenocarcinoma, Bladder carcinoma, Head and neck squamous cell carcinoma and in the PAN-cancer analysis

FAT1
Ensembl id ENSG00000083857
Mutated samples
Coding Sequence 341 (5.0%)
Protein Affecting 277 (4.1%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
LUAD F
BLCA F
HNSC FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FAT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 81 80 21.33
Lung adenocarcinoma Yes 31 30 7.67
Bladder carcinoma Yes 13 12 12.24
Small cell lung carcinoma Yes 4 4 5.80
Glioblastoma multiforme Yes 6 4 1.06
Prostate adenocarcinoma Yes 2 2 0.82
Lower grade glioma Yes 3 2 1.18
Cutaneous melanoma No 61 37 10.03
Uterine corpus endometrioid carcinoma No 29 25 10.87
Lung squamous cell carcinoma No 24 19 10.92
Breast carcinoma No 16 12 1.05
Serous ovarian adenocarcinoma No 13 11 3.48
Stomach adenocarcinoma No 12 10 6.21
Renal clear cell carcinoma No 10 7 1.68
Colorectal adenocarcinoma No 5 4 1.75
Esophageal carcinoma No 4 4 2.74
Multiple myeloma No 5 3 4.35
Medulloblastoma No 2 2 0.95
Pancreas adenocarcinoma No 2 2 0.93
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 11 1 0.34
Diffuse B cell lymphoma No 1 1 4.35
Acute lymphocytic leukemia No 1 1 0.82
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence