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ERBB2 is detected as a mutational cancer driver in 1 cancer type: Breast carcinoma

ERBB2
Ensembl id ENSG00000141736
Mutated samples
Coding Sequence 127 (1.9%)
Protein Affecting 89 (1.3%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
BRCA C
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ERBB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 19 17 1.48
Lung adenocarcinoma No 17 11 2.81
Cutaneous melanoma No 14 9 2.44
Head and neck squamous cell carcinoma No 13 8 2.13
Bladder carcinoma No 11 7 7.14
Stomach adenocarcinoma No 9 7 4.35
Colorectal adenocarcinoma No 7 6 2.62
Uterine corpus endometrioid carcinoma No 7 5 2.17
Renal clear cell carcinoma No 5 4 0.96
Lung squamous cell carcinoma No 5 3 1.72
Serous ovarian adenocarcinoma No 4 3 0.95
Esophageal carcinoma No 5 3 2.05
Prostate adenocarcinoma No 2 1 0.41
Thyroid carcinoma No 2 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 1 1 0.34
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 3 1 0.26
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence