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EPHA7 has not been detected as a mutational cancer driver

EPHA7
Ensembl id ENSG00000135333
Mutated samples
Coding Sequence 177 (2.6%)
Protein Affecting 130 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EPHA7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 41 11.11
Lung adenocarcinoma No 25 23 5.88
Head and neck squamous cell carcinoma No 20 14 3.73
Breast carcinoma No 8 8 0.70
Serous ovarian adenocarcinoma No 8 7 2.22
Lung squamous cell carcinoma No 6 5 2.87
Small cell lung carcinoma No 4 4 5.80
Stomach adenocarcinoma No 3 3 1.86
Colorectal adenocarcinoma No 4 3 1.31
Glioblastoma multiforme No 3 3 0.79
Esophageal carcinoma No 6 3 2.05
Prostate adenocarcinoma No 3 2 0.82
Bladder carcinoma No 3 2 2.04
Medulloblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 2 2 0.87
Non small cell lung carcinoma No 3 2 6.45
Chronic lymphocytic leukemia No 11 2 0.69
Hepatocarcinoma No 3 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Lower grade glioma No 1 1 0.59
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence