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EPHA3 has not been detected as a mutational cancer driver

EPHA3
Ensembl id ENSG00000044524
Mutated samples
Coding Sequence 225 (3.3%)
Protein Affecting 159 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EPHA3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 47 36 9.76
Lung adenocarcinoma No 37 30 7.67
Head and neck squamous cell carcinoma No 20 15 4.00
Lung squamous cell carcinoma No 16 11 6.32
Stomach adenocarcinoma No 13 10 6.21
Colorectal adenocarcinoma No 12 10 4.37
Breast carcinoma No 9 8 0.70
Esophageal carcinoma No 11 8 5.48
Uterine corpus endometrioid carcinoma No 7 5 2.17
Hepatocarcinoma No 7 4 4.44
Prostate adenocarcinoma No 4 3 1.23
Lower grade glioma No 3 3 1.78
Serous ovarian adenocarcinoma No 5 3 0.95
Glioblastoma multiforme No 4 3 0.79
Renal clear cell carcinoma No 2 2 0.48
Neuroblastoma No 2 2 0.95
Small cell lung carcinoma No 3 2 2.90
Bladder carcinoma No 1 1 1.02
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 2 1 0.47
Non small cell lung carcinoma No 1 1 3.23
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 15 0 0.00
Multiple myeloma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence