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EGR1 has not been detected as a mutational cancer driver

EGR1
Ensembl id ENSG00000120738
Mutated samples
Coding Sequence 48 (0.7%)
Protein Affecting 29 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EGR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 4 1.08
Multiple myeloma No 5 4 5.80
Stomach adenocarcinoma No 4 3 1.86
Lung adenocarcinoma No 3 2 0.51
Lung squamous cell carcinoma No 2 2 1.15
Renal clear cell carcinoma No 2 2 0.48
Head and neck squamous cell carcinoma No 2 2 0.53
Glioblastoma multiforme No 3 2 0.53
Hepatocarcinoma No 2 1 1.11
Breast carcinoma No 3 1 0.09
Neuroblastoma No 1 1 0.48
Uterine corpus endometrioid carcinoma No 2 1 0.43
Chronic lymphocytic leukemia No 2 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Prostate adenocarcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence