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DOCK2 has not been detected as a mutational cancer driver

DOCK2
Ensembl id ENSG00000134516
Mutated samples
Coding Sequence 244 (3.6%)
Protein Affecting 180 (2.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DOCK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 47 32 8.67
Lung adenocarcinoma No 28 22 5.63
Esophageal carcinoma No 19 17 11.64
Lung squamous cell carcinoma No 22 15 8.62
Head and neck squamous cell carcinoma No 20 14 3.73
Stomach adenocarcinoma No 13 12 7.45
Breast carcinoma No 16 10 0.87
Uterine corpus endometrioid carcinoma No 10 9 3.91
Colorectal adenocarcinoma No 11 8 3.49
Glioblastoma multiforme No 7 6 1.58
Bladder carcinoma No 6 5 5.10
Renal clear cell carcinoma No 6 5 1.20
Serous ovarian adenocarcinoma No 5 5 1.58
Hepatocarcinoma No 8 4 4.44
Pancreas adenocarcinoma No 4 4 1.87
Small cell lung carcinoma No 5 4 5.80
Prostate adenocarcinoma No 3 2 0.82
Acute myeloid leukemia No 2 2 1.02
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Chronic lymphocytic leukemia No 5 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence