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DENND5B has not been detected as a mutational cancer driver

DENND5B
Ensembl id ENSG00000170456
Mutated samples
Coding Sequence 76 (1.1%)
Protein Affecting 59 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DENND5B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 12 9 2.30
Cutaneous melanoma No 12 8 2.17
Breast carcinoma No 9 7 0.61
Bladder carcinoma No 6 6 6.12
Head and neck squamous cell carcinoma No 8 5 1.33
Renal clear cell carcinoma No 4 4 0.96
Lung squamous cell carcinoma No 3 3 1.72
Thyroid carcinoma No 3 3 0.93
Hepatocarcinoma No 2 2 2.22
Uterine corpus endometrioid carcinoma No 2 2 0.87
Multiple myeloma No 2 2 2.90
Stomach adenocarcinoma No 2 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Chronic lymphocytic leukemia No 3 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 2 1 0.68
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence