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COL5A3 has not been detected as a mutational cancer driver

COL5A3
Ensembl id ENSG00000080573
Mutated samples
Coding Sequence 197 (2.9%)
Protein Affecting 153 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all COL5A3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 70 56 15.18
Breast carcinoma No 13 11 0.96
Lung squamous cell carcinoma No 10 10 5.75
Lung adenocarcinoma No 13 9 2.30
Renal clear cell carcinoma No 9 9 2.16
Serous ovarian adenocarcinoma No 9 7 2.22
Stomach adenocarcinoma No 8 7 4.35
Thyroid carcinoma No 6 6 1.86
Uterine corpus endometrioid carcinoma No 8 6 2.61
Head and neck squamous cell carcinoma No 9 5 1.33
Prostate adenocarcinoma No 4 4 1.65
Bladder carcinoma No 5 4 4.08
Colorectal adenocarcinoma No 6 4 1.75
Hepatocarcinoma No 3 3 3.33
Neuroblastoma No 3 3 1.43
Small cell lung carcinoma No 4 3 4.35
Glioblastoma multiforme No 3 2 0.53
Esophageal carcinoma No 4 2 1.37
Acute myeloid leukemia No 2 1 0.51
Multiple myeloma No 1 1 1.45
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence