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COL1A1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

COL1A1
Ensembl id ENSG00000108821
Mutated samples
Coding Sequence 131 (1.9%)
Protein Affecting 103 (1.5%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all COL1A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 58 46 12.47
Head and neck squamous cell carcinoma Yes 9 7 1.87
Lung adenocarcinoma Yes 5 5 1.28
Stomach adenocarcinoma Yes 6 5 3.11
Neuroblastoma Yes 2 2 0.95
Lung squamous cell carcinoma No 9 8 4.60
Breast carcinoma No 9 6 0.52
Esophageal carcinoma No 7 6 4.11
Uterine corpus endometrioid carcinoma No 4 4 1.74
Colorectal adenocarcinoma No 4 4 1.75
Glioblastoma multiforme No 3 2 0.53
Prostate adenocarcinoma No 2 1 0.41
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 3 1 0.24
Thyroid carcinoma No 2 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence