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CHD8 is detected as a mutational cancer driver in 1 cancer type: Glioblastoma multiforme

CHD8
Ensembl id ENSG00000100888
Mutated samples
Coding Sequence 131 (1.9%)
Protein Affecting 103 (1.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
GBM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHD8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Glioblastoma multiforme Yes 10 10 2.64
Cutaneous melanoma No 29 21 5.69
Lung adenocarcinoma No 13 12 3.07
Head and neck squamous cell carcinoma No 11 10 2.67
Lung squamous cell carcinoma No 7 7 4.02
Uterine corpus endometrioid carcinoma No 8 7 3.04
Serous ovarian adenocarcinoma No 6 6 1.90
Esophageal carcinoma No 8 6 4.11
Bladder carcinoma No 5 4 4.08
Breast carcinoma No 7 4 0.35
Stomach adenocarcinoma No 5 3 1.86
Small cell lung carcinoma No 3 3 4.35
Pancreas adenocarcinoma No 3 2 0.93
Renal clear cell carcinoma No 3 2 0.48
Multiple myeloma No 2 2 2.90
Medulloblastoma No 2 1 0.48
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Lower grade glioma No 2 1 0.59
Prostate adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence