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CHD7 has not been detected as a mutational cancer driver

CHD7
Ensembl id ENSG00000171316
Mutated samples
Coding Sequence 182 (2.7%)
Protein Affecting 125 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHD7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 23 6.23
Lung squamous cell carcinoma No 24 16 9.20
Lung adenocarcinoma No 21 15 3.84
Bladder carcinoma No 9 9 9.18
Breast carcinoma No 18 9 0.78
Stomach adenocarcinoma No 12 9 5.59
Head and neck squamous cell carcinoma No 17 9 2.40
Renal clear cell carcinoma No 10 8 1.92
Uterine corpus endometrioid carcinoma No 10 7 3.04
Colorectal adenocarcinoma No 4 4 1.75
Prostate adenocarcinoma No 3 3 1.23
Pancreas adenocarcinoma No 2 2 0.93
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 2 2 1.18
Glioblastoma multiforme No 3 2 0.53
Esophageal carcinoma No 4 2 1.37
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 4 1 0.32
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence