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CHD2 has not been detected as a mutational cancer driver

CHD2
Ensembl id ENSG00000173575
Mutated samples
Coding Sequence 123 (1.8%)
Protein Affecting 92 (1.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CHD2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 29 20 5.42
Chronic lymphocytic leukemia No 12 10 3.45
Head and neck squamous cell carcinoma No 10 9 2.40
Bladder carcinoma No 7 7 7.14
Breast carcinoma No 10 7 0.61
Stomach adenocarcinoma No 10 6 3.73
Lung adenocarcinoma No 6 4 1.02
Lung squamous cell carcinoma No 5 4 2.30
Thyroid carcinoma No 4 4 1.24
Uterine corpus endometrioid carcinoma No 5 4 1.74
Colorectal adenocarcinoma No 4 4 1.75
Prostate adenocarcinoma No 3 3 1.23
Renal clear cell carcinoma No 4 3 0.72
Medulloblastoma No 2 2 0.95
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 3 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence