IntOGen - CD58 gene cancer mutations

CD58 is detected as a mutational cancer driver

CD58 reports

Methods
Mutation distribution

Gene details

CD58
Ensembl ID ENSG00000116815 Transcript ID ENST00000369489 Protein ID ENSP00000358501
Cancer types where is driver 2 Cohorts where is driver 2 Mutated samples 9 Mutations 135
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence