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CCAR1 is detected as a mutational cancer driver in 2 cancer types: Breast carcinoma, Serous ovarian adenocarcinoma and in the PAN-cancer analysis

CCAR1
Ensembl id ENSG00000060339
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 56 (0.8%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
BRCA F
OV F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CCAR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 12 12 1.05
Cutaneous melanoma Yes 12 8 2.17
Serous ovarian adenocarcinoma Yes 6 6 1.90
Medulloblastoma Yes 4 4 1.90
Head and neck squamous cell carcinoma Yes 8 4 1.07
Lung adenocarcinoma Yes 3 3 0.77
Renal clear cell carcinoma Yes 3 3 0.72
Bladder carcinoma Yes 2 2 2.04
Lung squamous cell carcinoma Yes 3 2 1.15
Stomach adenocarcinoma Yes 3 2 1.24
Uterine corpus endometrioid carcinoma No 4 4 1.74
Colorectal adenocarcinoma No 2 2 0.87
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence