IntOGen - BRCA2 gene cancer mutations

BRCA2 is detected as a mutational cancer driver

BRCA2 reports

Methods
Mutation distribution

Gene details

BRCA2
Gene ID ENSG00000139618 Transcript ID ENST00000380152 Protein ID ENSP00000369497
Cancer types where is driver 14 Cohorts where is driver 20 Mutated samples 163 Mutations 1,035
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence