IntOGen - BRAF gene cancer mutations

BRAF is detected as a mutational cancer driver

BRAF reports

Methods
In-silico saturation
Mutation distribution

Gene details

BRAF
Gene ID ENSG00000157764 Transcript ID ENST00000646891 Protein ID ENSP00000493543
Cancer types where is driver 28 Cohorts where is driver 57 Mutated samples 1,427 Mutations 1,799
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.

Model	Mutations	Driver mutations	Driver mutations (%)
BOWEL (Bowel)	9299	588	6.32
BRAIN (CNS/Brain)	9299	1176	12.65
COADREAD (Colorectal Adenocarcinoma)	9299	605	6.51
LNM (Lymphoid Neoplasm)	9299	315	3.39
LUAD (Lung Adenocarcinoma)	9299	3167	34.06
LUNG (Lung)	9299	2962	31.85
LYMPH (Lymphoid)	9299	349	3.75
MBN (Mature B-Cell Neoplasms)	9299	315	3.39
MEL (Melanoma)	9299	127	1.37
NHL (Non-Hodgkin Lymphoma)	9299	315	3.39
NSCLC (Non-Small Cell Lung Cancer)	9299	2931	31.52
PCM (Plasma Cell Myeloma)	9299	172	1.85
MEL (Cutaneous Melanoma)	9299	81	0.87
SKIN (Skin)	9299	127	1.37

Observed mutations in tumors

Plot
Table

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence