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ATM is detected as a mutational cancer driver in 6 cancer types: Prostate adenocarcinoma, Breast carcinoma, Renal clear cell carcinoma, Uterine corpus endometrioid carcinoma, Chronic lymphocytic leukemia, Colorectal adenocarcinoma and in the PAN-cancer analysis

ATM
Ensembl id ENSG00000149311
Mutated samples
Coding Sequence 237 (3.5%)
Protein Affecting 207 (3.0%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
PRAD F
BRCA F
RCCC F
UCEC F
CLL F
COREAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 26 24 2.09
Uterine corpus endometrioid carcinoma Yes 16 14 6.09
Prostate adenocarcinoma Yes 12 12 4.94
Renal clear cell carcinoma Yes 13 12 2.88
Chronic lymphocytic leukemia Yes 13 12 4.14
Colorectal adenocarcinoma Yes 11 11 4.80
Head and neck squamous cell carcinoma Yes 14 10 2.67
Pancreas adenocarcinoma Yes 3 3 1.40
Esophageal carcinoma Yes 7 3 2.05
Neuroblastoma Yes 3 2 0.95
Lung adenocarcinoma No 33 31 7.93
Cutaneous melanoma No 27 20 5.42
Bladder carcinoma No 12 11 11.22
Stomach adenocarcinoma No 14 11 6.83
Lung squamous cell carcinoma No 7 7 4.02
Hepatocarcinoma No 5 4 4.44
Thyroid carcinoma No 4 4 1.24
Serous ovarian adenocarcinoma No 4 4 1.27
Glioblastoma multiforme No 4 4 1.06
Small cell lung carcinoma No 2 2 2.90
Acute lymphocytic leukemia No 2 2 1.64
Medulloblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence