ARNTL mutations in 5 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Breast carcinoma, Lung squamous cell carcinoma, Uterine corpus endometrioid carcinoma, Colorectal adenocarcinoma, Esophageal carcinoma

Ensembl id ENSG00000133794
Mutated samples
Coding Sequence 36 (0.5%)
Protein Affecting 27 (0.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARNTL gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Breast carcinoma Yes 4 2 0.17
Lung squamous cell carcinoma Yes 2 2 1.15
Colorectal adenocarcinoma Yes 3 2 0.87
Esophageal carcinoma Yes 2 2 1.37
Cutaneous melanoma No 8 7 1.90
Stomach adenocarcinoma No 2 2 1.24
Head and neck squamous cell carcinoma No 4 2 0.53
Lung adenocarcinoma No 1 1 0.26
Hepatocarcinoma No 2 1 1.11
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence