Top
ARHGEF10 has not been detected as a mutational cancer driver

ARHGEF10
Ensembl id ENSG00000104728
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 53 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ARHGEF10 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 27 14 3.79
Stomach adenocarcinoma No 8 5 3.11
Breast carcinoma No 4 4 0.35
Lung squamous cell carcinoma No 5 4 2.30
Uterine corpus endometrioid carcinoma No 7 4 1.74
Prostate adenocarcinoma No 4 3 1.23
Esophageal carcinoma No 4 3 2.05
Lung adenocarcinoma No 5 2 0.51
Bladder carcinoma No 4 2 2.04
Renal clear cell carcinoma No 2 2 0.48
Chronic lymphocytic leukemia No 4 2 0.69
Serous ovarian adenocarcinoma No 2 2 0.63
Small cell lung carcinoma No 3 2 2.90
Glioblastoma multiforme No 5 2 0.53
Non small cell lung carcinoma No 1 1 3.23
Head and neck squamous cell carcinoma No 3 1 0.27
Pancreas adenocarcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence