IntOGen - APC gene cancer mutations

APC is detected as a mutational cancer driver

APC reports

Methods
In-silico saturation
Mutation distribution

Gene details

APC
Gene ID ENSG00000134982 Transcript ID ENST00000257430 Protein ID ENSP00000257430
Cancer types where is driver 22 Cohorts where is driver 43 Mutated samples 1,394 Mutations 2,805
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.

Model	Mutations	Driver mutations	Driver mutations (%)
BOWEL (Bowel)	27574	1453	5.27
COAD (Colon Adenocarcinoma)	27574	1352	4.90
COADREAD (Colorectal Adenocarcinoma)	27574	1453	5.27
EGC (Esophagogastric Adenocarcinoma)	27574	1289	4.67
LUNG (Lung)	27574	2250	8.16
NSCLC (Non-Small Cell Lung Cancer)	27574	2250	8.16
PRAD (Prostate Adenocarcinoma)	27574	1289	4.67
PROSTATE (Prostate)	27574	1289	4.67
READ (Rectal Adenocarcinoma)	27574	1289	4.67
STOMACH (Esophagus/Stomach)	27574	1289	4.67

Observed mutations in tumors

Plot
Table

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence