IntOGen - ALK gene cancer mutations

ALK is detected as a mutational cancer driver

ALK reports

Methods
Mutation distribution

Gene details

ALK
Ensembl ID ENSG00000171094 Transcript ID ENST00000389048 Protein ID ENSP00000373700
Cancer types where is driver 6 Cohorts where is driver 10 Mutated samples 79 Mutations 607
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence