IntOGen - AKT1 gene cancer mutations in PRAD

AKT1 is detected as a mutational cancer driver in Prostate Adenocarcinoma

AKT1 reports in Prostate Adenocarcinoma (PRAD)

Methods
Mutation distribution

Cancer type details

Prostate Adenocarcinoma
Cohorts 13 Samples 2,819 Mutations 9,128,298 Driver genes 104

Gene details

AKT1
Ensembl ID ENSG00000142208 Transcript ID ENST00000554581 Protein ID ENSP00000451828
Cohorts where is driver 5 Mutated samples 22 Mutated samples (%) 0.78 Mutations 28
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence