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AKR1B10 has not been detected as a mutational cancer driver

AKR1B10
Ensembl id ENSG00000198074
Mutated samples
Coding Sequence 50 (0.7%)
Protein Affecting 32 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AKR1B10 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 12 3.25
Lung adenocarcinoma No 7 7 1.79
Head and neck squamous cell carcinoma No 3 3 0.80
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 1 1 0.09
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 3 1 0.24
Lower grade glioma No 2 1 0.59
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence