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AKAP9 is detected as a mutational cancer driver in 1 cancer type: Glioblastoma multiforme and in the PAN-cancer analysis

AKAP9
Ensembl id ENSG00000127914
Mutated samples
Coding Sequence 232 (3.4%)
Protein Affecting 189 (2.8%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
GBM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AKAP9 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 26 20 1.74
Stomach adenocarcinoma Yes 13 10 6.21
Colorectal adenocarcinoma Yes 8 6 2.62
Glioblastoma multiforme Yes 6 6 1.58
Prostate adenocarcinoma Yes 6 4 1.65
Non small cell lung carcinoma Yes 4 4 12.90
Small cell lung carcinoma Yes 3 3 4.35
Thyroid carcinoma Yes 2 2 0.62
Diffuse B cell lymphoma Yes 2 2 8.70
Cutaneous melanoma No 48 38 10.30
Lung adenocarcinoma No 23 20 5.12
Head and neck squamous cell carcinoma No 21 18 4.80
Uterine corpus endometrioid carcinoma No 13 13 5.65
Renal clear cell carcinoma No 11 10 2.40
Esophageal carcinoma No 13 10 6.85
Lung squamous cell carcinoma No 12 9 5.17
Bladder carcinoma No 8 8 8.16
Serous ovarian adenocarcinoma No 5 4 1.27
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 5 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence