Top
AFF4 mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Bladder carcinoma, Breast carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma, Esophageal carcinoma

AFF4
Ensembl id ENSG00000072364
Mutated samples
Coding Sequence 86 (1.3%)
Protein Affecting 58 (0.9%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all AFF4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 23 18 4.88
Lung squamous cell carcinoma Yes 5 5 2.87
Bladder carcinoma Yes 4 4 4.08
Breast carcinoma Yes 7 4 0.35
Lung adenocarcinoma Yes 3 3 0.77
Stomach adenocarcinoma Yes 5 3 1.86
Esophageal carcinoma Yes 3 3 2.05
Serous ovarian adenocarcinoma Yes 2 2 0.63
Head and neck squamous cell carcinoma No 6 5 1.33
Uterine corpus endometrioid carcinoma No 6 4 1.74
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 4 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 8 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence