IntOGen - HRAS gene cancer mutations

HRAS is detected as a mutational cancer driver

HRAS reports

Methods
Mutation distribution

Gene details

HRAS
Ensembl ID ENSG00000174775 Transcript ID ENST00000451590 Protein ID ENSP00000407586
Cancer types where is driver 12 Cohorts where is driver 20 Mutated samples 173 Mutations 239
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence