CDKN2A is detected as a mutational cancer driver
CDKN2A reports
Gene details
CDKN2A |
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Ensembl ID
ENSG00000147889
Transcript ID ENST00000498124 Protein ID ENSP00000418915 |
Cancer types where is driver
19
Cohorts where is driver 55 Mutated samples 683 Mutations 727 |
Mode of action Loss of function |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
CM (Cutaneous melanoma of the skin) | 66 | 56 | 84.85 |
ESCA (Esophageal cancer) | 58 | 50 | 86.21 |
HNSC (Head and neck squamous cell carcinoma) | 48 | 41 | 85.42 |
LUNG_CANCER (Lung cancer) | 3 | 0 | 0.00 |
LUSC (Lung squamous cell carcinoma) | 44 | 36 | 81.82 |
NSCLC (Non-small cell lung cancer) | 38 | 30 | 78.95 |
PA (Pancreatic cancer) | 1 | 1 | 100.00 |
PAAD (Pancreas adenocarcinoma) | 68 | 59 | 86.76 |
SKIN (Skin cancer) | 12 | 9 | 75.00 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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