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32 mutational cancer drivers have been detected in this of Thyroid carcinoma (THCA) project from The Cancer Genome Atlas. The most mutated drivers are: BRAF, NRAS, HRAS, MLL3, EIF1AX, etc.



Thyroid Cancer TCGA obtained from Synapse
THCA Thyroid carcinoma
322 Samples
Driver / Mut. genes32 / 7119
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 316
in all genes 10749
Protein affecting mutations (PAMs)
in driver genes 305
in all genes 5121
This driver cloud represents the most recurrently mutated cancer driver genes in the Thyroid Cancer TCGA obtained from Synapse dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Thyroid Cancer TCGA obtained from Synapse dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
BRAF ENSG00000157764 183 182 56.52
NRAS ENSG00000213281 26 26 8.07
HRAS ENSG00000174775 12 12 3.73
MLL3 ENSG00000055609 5 5 1.55
EIF1AX ENSG00000173674 5 5 1.55
PPM1D ENSG00000170836 5 5 1.55
RPSAP58 ENSG00000205246 5 5 1.55
TP53 ENSG00000141510 3 3 0.93
CHD3 ENSG00000170004 7 3 0.93
DICER1 ENSG00000100697 3 3 0.93
MLL ENSG00000118058 4 3 0.93
AHNAK ENSG00000124942 4 3 0.93
PIK3CA ENSG00000121879 3 2 0.62
NSD1 ENSG00000165671 3 3 0.93
ZC3H11A ENSG00000058673 3 2 0.62
WIPF1 ENSG00000115935 3 2 0.62
GNAS ENSG00000087460 3 3 0.93
ARID2 ENSG00000189079 3 2 0.62
PTEN ENSG00000171862 2 2 0.62
KRAS ENSG00000133703 3 3 0.93
CTNNB1 ENSG00000168036 2 2 0.62
HNRPDL ENSG00000152795 2 2 0.62
TRIO ENSG00000038382 2 2 0.62
BPTF ENSG00000171634 2 2 0.62
TJP1 ENSG00000104067 2 2 0.62
PPP2R1A ENSG00000105568 2 2 0.62
AKAP9 ENSG00000127914 2 2 0.62
LDHA ENSG00000134333 2 2 0.62
PRPF8 ENSG00000174231 2 2 0.62
CDK12 ENSG00000167258 2 2 0.62
NCK1 ENSG00000158092 2 2 0.62
ARHGAP26 ENSG00000145819 2 2 0.62