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105 mutational cancer drivers have been detected in this of Renal clear cell carcinoma (RCCC) project from The Cancer Genome Atlas. The most mutated drivers are: VHL, PBRM1, SETD2, BAP1, MTOR, etc.



Kidney clear cell carcinoma TCGA
RCCC Renal clear cell carcinoma
417 Samples
Driver / Mut. genes105 / 17272
The Cancer Genome Atlas
doi:10.1038/nature12222
Coding sequence mutations (CSMs)
in driver genes 969
in all genes 41084
Protein affecting mutations (PAMs)
in driver genes 859
in all genes 20546
This driver cloud represents the most recurrently mutated cancer driver genes in the Kidney clear cell carcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Kidney clear cell carcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
VHL ENSG00000134086 219 216 51.80
PBRM1 ENSG00000163939 140 138 33.09
SETD2 ENSG00000181555 50 49 11.75
BAP1 ENSG00000163930 43 39 9.35
MTOR ENSG00000198793 29 25 6.00
KDM5C ENSG00000126012 27 27 6.47
PTEN ENSG00000171862 18 18 4.32
MLL3 ENSG00000055609 17 16 3.84
PABPC1 ENSG00000070756 15 14 3.36
ATM ENSG00000149311 13 12 2.88
ARID1A ENSG00000117713 12 12 2.88
PSME3 ENSG00000131467 9 5 1.20
CLTC ENSG00000141367 7 7 1.68
ZNF814 ENSG00000204514 7 6 1.44
EGFR ENSG00000146648 7 7 1.68
WHSC1L1 ENSG00000147548 6 6 1.44
TP53BP1 ENSG00000067369 6 6 1.44
NFE2L2 ENSG00000116044 5 5 1.20
ASH1L ENSG00000116539 10 3 0.72
ARID2 ENSG00000189079 8 3 0.72
NCOR1 ENSG00000141027 7 3 0.72
FUS ENSG00000089280 3 2 0.48
HSP90AB1 ENSG00000096384 7 3 0.72
RPL5 ENSG00000122406 6 2 0.48
MAX ENSG00000125952 5 2 0.48
CAD ENSG00000084774 5 3 0.72
KDM6A ENSG00000147050 5 3 0.72
ARID1B ENSG00000049618 5 4 0.96
TAOK2 ENSG00000149930 5 3 0.72
DDX5 ENSG00000108654 5 2 0.48
DHX15 ENSG00000109606 4 2 0.48
PPP2R1A ENSG00000105568 5 2 0.48
MET ENSG00000105976 5 3 0.72
EIF4A2 ENSG00000156976 5 3 0.72
TCF12 ENSG00000140262 4 3 0.72
RASA1 ENSG00000145715 4 3 0.72
ELF1 ENSG00000120690 4 4 0.96
BMPR2 ENSG00000204217 3 3 0.72
ERBB2IP ENSG00000112851 4 3 0.72
BCOR ENSG00000183337 4 3 0.72
CHEK2 ENSG00000183765 4 3 0.72
DICER1 ENSG00000100697 4 2 0.48
CDC73 ENSG00000134371 4 2 0.48
SIN3A ENSG00000169375 4 2 0.48
MKL1 ENSG00000196588 4 2 0.48
MGA ENSG00000174197 4 3 0.72
ACO1 ENSG00000122729 4 3 0.72
EIF2C3 ENSG00000126070 4 3 0.72
CNOT3 ENSG00000088038 4 3 0.72
TBL1XR1 ENSG00000177565 3 3 0.72
PSMA6 ENSG00000100902 3 3 0.72
CUL1 ENSG00000055130 3 3 0.72
EZH2 ENSG00000106462 3 3 0.72
DDX3X ENSG00000215301 3 3 0.72
TRIO ENSG00000038382 3 2 0.48
ITSN1 ENSG00000205726 3 2 0.48
ACTG1 ENSG00000184009 3 3 0.72
MED17 ENSG00000042429 3 3 0.72
KEAP1 ENSG00000079999 3 2 0.48
DIS3 ENSG00000083520 3 3 0.72
SOX9 ENSG00000125398 3 3 0.72
CAT ENSG00000121691 3 2 0.48
CCAR1 ENSG00000060339 3 3 0.72
ZFP36L2 ENSG00000152518 3 3 0.72
CSDA ENSG00000060138 3 3 0.72
EIF4G1 ENSG00000114867 3 3 0.72
TJP2 ENSG00000119139 3 2 0.48
SMC1A ENSG00000072501 3 2 0.48
BCLAF1 ENSG00000029363 3 2 0.48
LPHN2 ENSG00000117114 3 2 0.48
EEF1A1 ENSG00000156508 3 2 0.48
AHR ENSG00000106546 3 3 0.72
CDH1 ENSG00000039068 3 2 0.48
NUP98 ENSG00000110713 3 2 0.48
WT1 ENSG00000184937 3 3 0.72
PCSK6 ENSG00000140479 3 3 0.72
FMR1 ENSG00000102081 3 3 0.72
ARHGAP26 ENSG00000145819 3 3 0.72
CNOT4 ENSG00000080802 3 2 0.48
EIF2AK3 ENSG00000172071 2 2 0.48
HNRPDL ENSG00000152795 2 2 0.48
SMAD2 ENSG00000175387 2 2 0.48
PCDH18 ENSG00000189184 2 2 0.48
LCP1 ENSG00000136167 2 2 0.48
IDH1 ENSG00000138413 2 2 0.48
PIK3R1 ENSG00000145675 2 2 0.48
FLT3 ENSG00000122025 2 2 0.48
NTN4 ENSG00000074527 2 2 0.48
SRGAP3 ENSG00000196220 2 2 0.48
RPL22 ENSG00000116251 2 2 0.48
G3BP2 ENSG00000138757 2 2 0.48
TJP1 ENSG00000104067 2 2 0.48
LRP6 ENSG00000070018 2 2 0.48
AKT1 ENSG00000142208 2 2 0.48
COPS2 ENSG00000166200 2 2 0.48
CTCF ENSG00000102974 2 2 0.48
PIP5K1A ENSG00000143398 2 2 0.48
ATF1 ENSG00000123268 2 2 0.48
PHF6 ENSG00000156531 2 2 0.48
HLF ENSG00000108924 2 2 0.48
MED24 ENSG00000008838 2 2 0.48
FAM123B ENSG00000184675 2 2 0.48
HDAC9 ENSG00000048052 2 2 0.48
SHMT1 ENSG00000176974 2 2 0.48
SEC24D ENSG00000150961 2 2 0.48