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88 mutational cancer drivers have been detected in this of Prostate adenocarcinoma (PRAD) project from The Cancer Genome Atlas. The most mutated drivers are: SPOP, TP53, ZNF814, PTEN, ATM, etc.



Prostate Cancer TCGA obtained from Synapse
PRAD Prostate adenocarcinoma
243 Samples
Driver / Mut. genes88 / 10872
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 372
in all genes 19342
Protein affecting mutations (PAMs)
in driver genes 326
in all genes 9006
This driver cloud represents the most recurrently mutated cancer driver genes in the Prostate Cancer TCGA obtained from Synapse dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Prostate Cancer TCGA obtained from Synapse dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
SPOP ENSG00000121067 23 22 9.05
TP53 ENSG00000141510 22 21 8.64
ZNF814 ENSG00000204514 13 6 2.47
PTEN ENSG00000171862 13 13 5.35
ATM ENSG00000149311 12 12 4.94
CTNNB1 ENSG00000168036 9 9 3.70
EEF1B2 ENSG00000114942 5 5 2.06
AHNAK ENSG00000124942 6 6 2.47
CHEK2 ENSG00000183765 4 4 1.65
MLL2 ENSG00000167548 7 6 2.47
FIP1L1 ENSG00000145216 6 4 1.65
KDM6A ENSG00000147050 6 6 2.47
CNTNAP1 ENSG00000108797 6 6 2.47
FRG1 ENSG00000109536 5 3 1.23
SCAI ENSG00000173611 5 5 2.06
BRAF ENSG00000157764 5 4 1.65
PLXNA1 ENSG00000114554 5 3 1.23
ZFHX3 ENSG00000140836 4 4 1.65
SMARCA1 ENSG00000102038 5 5 2.06
ARFGAP3 ENSG00000242247 5 5 2.06
MED12 ENSG00000184634 5 5 2.06
SMAD4 ENSG00000141646 3 3 1.23
NKX3-1 ENSG00000167034 4 4 1.65
CDC27 ENSG00000004897 3 3 1.23
SMARCB1 ENSG00000099956 3 3 1.23
IDH1 ENSG00000138413 3 3 1.23
HNF1A ENSG00000135100 3 3 1.23
NOTCH2 ENSG00000134250 3 3 1.23
WHSC1L1 ENSG00000147548 3 3 1.23
CDKN1B ENSG00000111276 3 3 1.23
PRPF8 ENSG00000174231 3 3 1.23
CNOT3 ENSG00000088038 3 3 1.23
TP53BP1 ENSG00000067369 3 3 1.23
WNT5A ENSG00000114251 2 2 0.82
ADCY1 ENSG00000164742 2 2 0.82
CHD3 ENSG00000170004 6 2 0.82
AKAP9 ENSG00000127914 6 4 1.65
ARID1B ENSG00000049618 4 3 1.23
MECOM ENSG00000085276 4 3 1.23
PCDH18 ENSG00000189184 4 3 1.23
BCOR ENSG00000183337 4 2 0.82
AQR ENSG00000021776 3 3 1.23
CHD4 ENSG00000111642 3 2 0.82
CASP1 ENSG00000137752 4 2 0.82
EGFR ENSG00000146648 3 3 1.23
CUL3 ENSG00000036257 3 3 1.23
EIF2AK3 ENSG00000172071 3 3 1.23
TBX3 ENSG00000135111 3 3 1.23
TRIO ENSG00000038382 3 3 1.23
TAOK2 ENSG00000149930 3 3 1.23
BPTF ENSG00000171634 3 2 0.82
TJP1 ENSG00000104067 3 2 0.82
EP300 ENSG00000100393 3 3 1.23
THRAP3 ENSG00000054118 3 2 0.82
SETDB1 ENSG00000143379 3 2 0.82
CUL2 ENSG00000108094 3 3 1.23
GNAS ENSG00000087460 3 2 0.82
BNC2 ENSG00000173068 2 2 0.82
NOTCH1 ENSG00000148400 3 2 0.82
BCLAF1 ENSG00000029363 3 2 0.82
CNOT1 ENSG00000125107 3 2 0.82
HSP90AB1 ENSG00000096384 3 2 0.82
NUP98 ENSG00000110713 2 2 0.82
MYH10 ENSG00000133026 3 3 1.23
NAP1L1 ENSG00000187109 2 2 0.82
TBL1XR1 ENSG00000177565 2 2 0.82
SVEP1 ENSG00000165124 2 2 0.82
ATIC ENSG00000138363 2 2 0.82
FN1 ENSG00000115414 2 2 0.82
HSPA8 ENSG00000109971 2 2 0.82
IRS2 ENSG00000185950 2 2 0.82
HGF ENSG00000019991 2 2 0.82
APC ENSG00000134982 2 2 0.82
CEP290 ENSG00000198707 2 2 0.82
KEAP1 ENSG00000079999 2 2 0.82
FGFR2 ENSG00000066468 2 2 0.82
PIK3CB ENSG00000051382 2 2 0.82
RPSAP58 ENSG00000205246 2 2 0.82
G3BP2 ENSG00000138757 2 2 0.82
CAT ENSG00000121691 2 2 0.82
ATRX ENSG00000085224 2 2 0.82
CHD1L ENSG00000131778 2 2 0.82
ERCC2 ENSG00000104884 2 2 0.82
EIF4G1 ENSG00000114867 2 2 0.82
TJP2 ENSG00000119139 2 2 0.82
FAT1 ENSG00000083857 2 2 0.82
CDH1 ENSG00000039068 2 2 0.82
HRAS ENSG00000174775 2 2 0.82