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13 mutational cancer drivers have been detected in this of Pancreas adenocarcinoma (PAAD) project from Queensland Centre for Medical Genomics. The most mutated drivers are: KRAS, SMAD4, TP53, TGFBR2, EPC1, etc.



Pancreatic cancer QCMG
PAAD Pancreas adenocarcinoma
67 Samples
Driver / Mut. genes13 / 1808
Queensland Centre for Medical Genomics
PMID:21436628
Coding sequence mutations (CSMs)
in driver genes 112
in all genes 2153
Protein affecting mutations (PAMs)
in driver genes 109
in all genes 1123
This driver cloud represents the most recurrently mutated cancer driver genes in the Pancreatic cancer QCMG dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Pancreatic cancer QCMG dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
KRAS ENSG00000133703 63 63 94.03
SMAD4 ENSG00000141646 9 9 13.43
TP53 ENSG00000141510 9 9 13.43
TGFBR2 ENSG00000163513 3 3 4.48
EPC1 ENSG00000120616 3 3 4.48
ARID1A ENSG00000117713 3 3 4.48
ACVR1B ENSG00000135503 2 2 2.99
MLL3 ENSG00000055609 4 3 4.48
ATM ENSG00000149311 3 3 4.48
ARID2 ENSG00000189079 3 3 4.48
CREBBP ENSG00000005339 2 2 2.99
ARHGAP35 ENSG00000160007 2 2 2.99
MAP2K4 ENSG00000065559 2 2 2.99