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14 mutational cancer drivers have been detected in this of Pancreas adenocarcinoma (PAAD) project from Johns Hopkins University. The most mutated drivers are: KRAS, TP53, SMAD4, MLL3, TGFBR2, etc.



Pancreatic cancer Johns Hopkins University
PAAD Pancreas adenocarcinoma
114 Samples
Driver / Mut. genes14 / 1949
Johns Hopkins University
PMID:18772397
Coding sequence mutations (CSMs)
in driver genes 286
in all genes 2620
Protein affecting mutations (PAMs)
in driver genes 282
in all genes 1379
This driver cloud represents the most recurrently mutated cancer driver genes in the Pancreatic cancer Johns Hopkins University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Pancreatic cancer Johns Hopkins University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
KRAS ENSG00000133703 113 113 99.12
TP53 ENSG00000141510 94 92 80.70
SMAD4 ENSG00000141646 31 31 27.19
MLL3 ENSG00000055609 9 9 7.89
TGFBR2 ENSG00000163513 8 8 7.02
SMARCA4 ENSG00000127616 4 4 3.51
PCDH18 ENSG00000189184 3 3 2.63
AHNAK ENSG00000124942 3 3 2.63
SF3B1 ENSG00000115524 2 2 1.75
PBRM1 ENSG00000163939 2 2 1.75
EP300 ENSG00000100393 2 2 1.75
ARID1A ENSG00000117713 2 2 1.75
ANK3 ENSG00000151150 2 2 1.75
PCSK6 ENSG00000140479 2 2 1.75