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83 mutational cancer drivers have been detected in this of Serous ovarian adenocarcinoma (OV) project from The Cancer Genome Atlas. The most mutated drivers are: TP53, NF1, BRCA2, BRCA1, CHD4, etc.



Ovarian serous cystadenocarcinoma TCGA
OV Serous ovarian adenocarcinoma
316 Samples
Driver / Mut. genes83 / 13462
The Cancer Genome Atlas
doi:10.1038/nature10166
Coding sequence mutations (CSMs)
in driver genes 599
in all genes 26845
Protein affecting mutations (PAMs)
in driver genes 544
in all genes 14718
This driver cloud represents the most recurrently mutated cancer driver genes in the Ovarian serous cystadenocarcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Ovarian serous cystadenocarcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 301 295 93.35
NF1 ENSG00000196712 15 12 3.80
BRCA2 ENSG00000139618 11 10 3.16
BRCA1 ENSG00000012048 11 11 3.48
CHD4 ENSG00000111642 9 8 2.53
CDK12 ENSG00000167258 9 8 2.53
RB1 ENSG00000139687 7 6 1.90
SETD2 ENSG00000181555 6 6 1.90
CCAR1 ENSG00000060339 6 6 1.90
F8 ENSG00000185010 5 5 1.58
STAG2 ENSG00000101972 9 3 0.95
MKL1 ENSG00000196588 6 3 0.95
FAM123B ENSG00000184675 6 3 0.95
PIK3CA ENSG00000121879 5 2 0.63
NR4A2 ENSG00000153234 5 3 0.95
NDRG1 ENSG00000104419 4 3 0.95
BMPR2 ENSG00000204217 4 3 0.95
MLH1 ENSG00000076242 4 2 0.63
SOS1 ENSG00000115904 4 3 0.95
MAP4K3 ENSG00000011566 4 4 1.27
ASPM ENSG00000066279 4 3 0.95
CSDE1 ENSG00000009307 4 2 0.63
TJP1 ENSG00000104067 4 3 0.95
TP53BP1 ENSG00000067369 4 3 0.95
YBX1 ENSG00000065978 3 3 0.95
TOM1 ENSG00000100284 3 3 0.95
CTNNB1 ENSG00000168036 3 2 0.63
EIF2AK3 ENSG00000172071 3 3 0.95
BAP1 ENSG00000163930 3 2 0.63
DLG1 ENSG00000075711 3 3 0.95
ERBB2IP ENSG00000112851 3 3 0.95
TBX3 ENSG00000135111 3 3 0.95
TRIO ENSG00000038382 3 2 0.63
TGFBR2 ENSG00000163513 3 3 0.95
CLASP2 ENSG00000163539 3 2 0.63
FLT3 ENSG00000122025 3 3 0.95
ITSN1 ENSG00000205726 3 2 0.63
FBXW7 ENSG00000109670 3 3 0.95
ASH1L ENSG00000116539 3 3 0.95
DNMT3A ENSG00000119772 3 3 0.95
NRAS ENSG00000213281 3 2 0.63
MLL2 ENSG00000167548 3 2 0.63
SIN3A ENSG00000169375 3 2 0.63
CHD1L ENSG00000131778 3 2 0.63
ARID1A ENSG00000117713 3 3 0.95
CASP1 ENSG00000137752 3 3 0.95
SETDB1 ENSG00000143379 3 3 0.95
BAZ2B ENSG00000123636 3 2 0.63
CUL2 ENSG00000108094 3 2 0.63
GNAS ENSG00000087460 3 3 0.95
NOTCH1 ENSG00000148400 3 2 0.63
HDAC3 ENSG00000171720 3 2 0.63
RHOA ENSG00000067560 2 2 0.63
TCF7L2 ENSG00000148737 2 2 0.63
POLR2B ENSG00000047315 2 2 0.63
MECOM ENSG00000085276 2 2 0.63
BRAF ENSG00000157764 2 2 0.63
ATIC ENSG00000138363 2 2 0.63
NSD1 ENSG00000165671 2 2 0.63
MAP3K4 ENSG00000085511 2 2 0.63
GPS2 ENSG00000132522 2 2 0.63
HGF ENSG00000019991 2 2 0.63
ACTG1 ENSG00000184009 2 2 0.63
TFDP1 ENSG00000198176 2 2 0.63
GOLGA5 ENSG00000066455 2 2 0.63
CCT5 ENSG00000150753 2 2 0.63
DDX5 ENSG00000108654 2 2 0.63
HSP90AA1 ENSG00000080824 2 2 0.63
ATR ENSG00000175054 2 2 0.63
ATRX ENSG00000085224 2 2 0.63
ACO1 ENSG00000122729 2 2 0.63
CLSPN ENSG00000092853 2 2 0.63
ATF1 ENSG00000123268 2 2 0.63
EIF4A2 ENSG00000156976 2 2 0.63
LPHN2 ENSG00000117114 2 2 0.63
NCKAP1 ENSG00000061676 2 2 0.63
AFF4 ENSG00000072364 2 2 0.63
PTEN ENSG00000171862 2 2 0.63
STAG1 ENSG00000118007 2 2 0.63
KRAS ENSG00000133703 2 2 0.63
FMR1 ENSG00000102081 2 2 0.63
MYH10 ENSG00000133026 2 2 0.63
MED12 ENSG00000184634 2 2 0.63