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11 mutational cancer drivers have been detected in this of Non small cell lung carcinoma (NSCLC) project from Medical College of Wisconsin. The most mutated drivers are: TP53, KALRN, MLL3, HGF, APC, etc.



Non small cell lung cancer MCW
NSCLC Non small cell lung carcinoma
31 Samples
Driver / Mut. genes11 / 7210
Medical College of Wisconsin
PMID:22510280
Coding sequence mutations (CSMs)
in driver genes 47
in all genes 10036
Protein affecting mutations (PAMs)
in driver genes 38
in all genes 2752
This driver cloud represents the most recurrently mutated cancer driver genes in the Non small cell lung cancer MCW dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Non small cell lung cancer MCW dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 10 10 32.26
KALRN ENSG00000160145 5 3 9.68
MLL3 ENSG00000055609 3 3 9.68
HGF ENSG00000019991 4 2 6.45
APC ENSG00000134982 3 2 6.45
KEAP1 ENSG00000079999 3 3 9.68
AKAP9 ENSG00000127914 4 4 12.90
RB1 ENSG00000139687 3 2 6.45
SMARCA4 ENSG00000127616 2 2 6.45
KRAS ENSG00000133703 2 2 6.45
SEC24D ENSG00000150961 2 2 6.45