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27 mutational cancer drivers have been detected in this of Neuroblastoma (NB) project from Broad Institute. The most mutated drivers are: ALK, PTPN11, ATRX, MYCN, NF1, etc.



Neuroblastoma Broad obtained from AlexandrovEtAl
NB Neuroblastoma
210 Samples
Driver / Mut. genes27 / 5464
Broad Institute
doi:10.1038/ng.2529
Coding sequence mutations (CSMs)
in driver genes 92
in all genes 7150
Protein affecting mutations (PAMs)
in driver genes 87
in all genes 3973
This driver cloud represents the most recurrently mutated cancer driver genes in the Neuroblastoma Broad obtained from AlexandrovEtAl dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Neuroblastoma Broad obtained from AlexandrovEtAl dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
ALK ENSG00000171094 19 19 9.05
PTPN11 ENSG00000179295 7 7 3.33
ATRX ENSG00000085224 5 5 2.38
MYCN ENSG00000134323 4 4 1.90
NF1 ENSG00000196712 3 2 0.95
MACF1 ENSG00000127603 4 3 1.43
TRIO ENSG00000038382 3 3 1.43
PIK3CB ENSG00000051382 3 2 0.95
LRP6 ENSG00000070018 3 2 0.95
ATM ENSG00000149311 3 2 0.95
AHR ENSG00000106546 3 3 1.43
ANK3 ENSG00000151150 3 3 1.43
STAG1 ENSG00000118007 3 3 1.43
TAF1 ENSG00000147133 2 2 0.95
PIK3CA ENSG00000121879 2 2 0.95
MECOM ENSG00000085276 2 2 0.95
PBRM1 ENSG00000163939 2 2 0.95
CREBBP ENSG00000005339 2 2 0.95
CEP290 ENSG00000198707 2 2 0.95
KLF4 ENSG00000136826 2 2 0.95
NRAS ENSG00000213281 2 2 0.95
MLL2 ENSG00000167548 2 2 0.95
EIF2C3 ENSG00000126070 2 2 0.95
COL1A1 ENSG00000108821 2 2 0.95
MET ENSG00000105976 2 2 0.95
ARID1A ENSG00000117713 2 2 0.95
NOTCH1 ENSG00000148400 2 2 0.95