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16 mutational cancer drivers have been detected in this of Medulloblastoma (MB) project from Deutsches Krebsforschungszentrum. The most mutated drivers are: CTNNB1, DDX3X, PTCH1, SMARCA4, MLL2, etc.



Pediatric brain tumors DKFZ
MB Medulloblastoma
110 Samples
Driver / Mut. genes16 / 1001
Deutsches Krebsforschungszentrum
PMID:22265402
Coding sequence mutations (CSMs)
in driver genes 78
in all genes 1188
Protein affecting mutations (PAMs)
in driver genes 77
in all genes 812
This driver cloud represents the most recurrently mutated cancer driver genes in the Pediatric brain tumors DKFZ dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Pediatric brain tumors DKFZ dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
CTNNB1 ENSG00000168036 15 15 13.64
DDX3X ENSG00000215301 10 10 9.09
PTCH1 ENSG00000185920 8 7 6.36
SMARCA4 ENSG00000127616 6 6 5.45
MLL2 ENSG00000167548 6 6 5.45
TP53 ENSG00000141510 5 5 4.55
KDM6A ENSG00000147050 5 5 4.55
BCOR ENSG00000183337 3 3 2.73
MLL3 ENSG00000055609 3 3 2.73
NF1 ENSG00000196712 3 3 2.73
TAF1 ENSG00000147133 2 2 1.82
PIK3CA ENSG00000121879 2 2 1.82
ARID1B ENSG00000049618 2 2 1.82
CCAR1 ENSG00000060339 2 2 1.82
MGA ENSG00000174197 2 2 1.82
BCLAF1 ENSG00000029363 2 2 1.82