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147 mutational cancer drivers have been detected in this of Lung squamous cell carcinoma (LUSC) project from The Cancer Genome Atlas. The most mutated drivers are: TP53, MLL2, PIK3CA, NFE2L2, CDKN2A, etc.



Lung squamous cell carcinoma TCGA
LUSC Lung squamous cell carcinoma
174 Samples
Driver / Mut. genes147 / 20703
The Cancer Genome Atlas
doi:10.1038/nature11404
Coding sequence mutations (CSMs)
in driver genes 1013
in all genes 80088
Protein affecting mutations (PAMs)
in driver genes 859
in all genes 43317
This driver cloud represents the most recurrently mutated cancer driver genes in the Lung squamous cell carcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Lung squamous cell carcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 143 139 79.89
MLL2 ENSG00000167548 38 36 20.69
PIK3CA ENSG00000121879 27 26 14.94
NFE2L2 ENSG00000116044 26 26 14.94
CDKN2A ENSG00000147889 26 26 14.94
KEAP1 ENSG00000079999 21 21 12.07
NF1 ENSG00000196712 22 19 10.92
FN1 ENSG00000115414 19 17 9.77
NOTCH1 ENSG00000148400 16 14 8.05
PTEN ENSG00000171862 14 14 8.05
ARID1A ENSG00000117713 13 12 6.90
RB1 ENSG00000139687 12 12 6.90
CNOT4 ENSG00000080802 9 8 4.60
RASA1 ENSG00000145715 7 7 4.02
ACTG2 ENSG00000163017 6 6 3.45
PRPF8 ENSG00000174231 6 5 2.87
ERBB2IP ENSG00000112851 5 5 2.87
RGS3 ENSG00000138835 6 6 3.45
DHX9 ENSG00000135829 5 5 2.87
ABL2 ENSG00000143322 5 5 2.87
MYB ENSG00000118513 5 5 2.87
CTTN ENSG00000085733 5 5 2.87
TBX3 ENSG00000135111 9 5 2.87
MLL ENSG00000118058 10 5 2.87
TAOK2 ENSG00000149930 9 3 1.72
ARID1B ENSG00000049618 8 5 2.87
CDC73 ENSG00000134371 8 4 2.30
WT1 ENSG00000184937 7 4 2.30
STAG1 ENSG00000118007 8 5 2.87
EZH2 ENSG00000106462 7 4 2.30
MLH1 ENSG00000076242 6 2 1.15
MED17 ENSG00000042429 5 5 2.87
SRGAP3 ENSG00000196220 7 5 2.87
SPTAN1 ENSG00000197694 7 4 2.30
SIN3A ENSG00000169375 7 5 2.87
UPF3B ENSG00000125351 5 4 2.30
MKL1 ENSG00000196588 6 4 2.30
SETDB1 ENSG00000143379 6 4 2.30
EIF4A2 ENSG00000156976 7 2 1.15
NUP98 ENSG00000110713 7 3 1.72
EGFR ENSG00000146648 6 5 2.87
SMAD4 ENSG00000141646 6 5 2.87
HLA-A ENSG00000206503 5 5 2.87
CLASP2 ENSG00000163539 5 5 2.87
NCF2 ENSG00000116701 6 3 1.72
HSP90AA1 ENSG00000080824 5 3 1.72
FXR1 ENSG00000114416 6 4 2.30
ZFP36L2 ENSG00000152518 6 6 3.45
EIF2C3 ENSG00000126070 4 3 1.72
AQR ENSG00000021776 6 5 2.87
MET ENSG00000105976 6 3 1.72
GATA3 ENSG00000107485 6 5 2.87
KDM5C ENSG00000126012 6 5 2.87
MED24 ENSG00000008838 6 4 2.30
AFF4 ENSG00000072364 5 5 2.87
CLOCK ENSG00000134852 4 4 2.30
MAP3K1 ENSG00000095015 5 3 1.72
CHD3 ENSG00000170004 5 3 1.72
MUC20 ENSG00000176945 5 4 2.30
DLG1 ENSG00000075711 5 4 2.30
CUL1 ENSG00000055130 5 4 2.30
MAP3K4 ENSG00000085511 5 3 1.72
SETD2 ENSG00000181555 5 5 2.87
TGFBR2 ENSG00000163513 5 3 1.72
ITSN1 ENSG00000205726 5 4 2.30
FGFR2 ENSG00000066468 5 4 2.30
FOXP1 ENSG00000114861 5 4 2.30
NR4A2 ENSG00000153234 5 4 2.30
SYNCRIP ENSG00000135316 5 5 2.87
CNOT3 ENSG00000088038 5 3 1.72
STK11 ENSG00000118046 5 3 1.72
FUBP1 ENSG00000162613 4 4 2.30
PCSK6 ENSG00000140479 5 4 2.30
FMR1 ENSG00000102081 5 4 2.30
HRAS ENSG00000174775 5 5 2.87
MEN1 ENSG00000133895 4 3 1.72
CTNNB1 ENSG00000168036 4 3 1.72
TBL1XR1 ENSG00000177565 4 2 1.15
IREB2 ENSG00000136381 4 2 1.15
ELF1 ENSG00000120690 4 3 1.72
PTPN11 ENSG00000179295 4 3 1.72
HSPA8 ENSG00000109971 4 3 1.72
CHEK2 ENSG00000183765 4 2 1.15
PIK3CB ENSG00000051382 4 3 1.72
TFDP2 ENSG00000114126 4 4 2.30
G3BP2 ENSG00000138757 4 3 1.72
CIC ENSG00000079432 4 4 2.30
SUZ12 ENSG00000178691 4 4 2.30
CSDA ENSG00000060138 4 4 2.30
ARFGEF2 ENSG00000124198 3 2 1.15
WIPF1 ENSG00000115935 4 4 2.30
HLF ENSG00000108924 4 4 2.30
FGFR3 ENSG00000068078 4 4 2.30
SF3B1 ENSG00000115524 4 4 2.30
NFATC4 ENSG00000100968 3 2 1.15
TOM1 ENSG00000100284 3 2 1.15
NDRG1 ENSG00000104419 3 3 1.72
CAST ENSG00000153113 3 3 1.72
PCDH18 ENSG00000189184 3 3 1.72
GNAI1 ENSG00000127955 3 3 1.72
TFDP1 ENSG00000198176 3 3 1.72
RTN4 ENSG00000115310 3 2 1.15
PAX5 ENSG00000196092 3 3 1.72
PPP2R5C ENSG00000078304 3 3 1.72
ZC3H11A ENSG00000058673 3 3 1.72
CSDE1 ENSG00000009307 3 2 1.15
B2M ENSG00000166710 3 2 1.15
ADAM10 ENSG00000137845 3 3 1.72
DHX15 ENSG00000109606 3 3 1.72
CCAR1 ENSG00000060339 3 2 1.15
CHD1L ENSG00000131778 3 2 1.15
COPS2 ENSG00000166200 3 3 1.72
PIP5K1A ENSG00000143398 3 3 1.72
ARHGEF6 ENSG00000129675 3 2 1.15
HSP90AB1 ENSG00000096384 3 3 1.72
RAD21 ENSG00000164754 3 2 1.15
CDH1 ENSG00000039068 3 3 1.72
MAP2K1 ENSG00000169032 3 2 1.15
NCK1 ENSG00000158092 3 2 1.15
SEC24D ENSG00000150961 3 2 1.15
CASP8 ENSG00000064012 3 2 1.15
GPSM2 ENSG00000121957 2 2 1.15
SMAD2 ENSG00000175387 2 2 1.15
RPL5 ENSG00000122406 2 2 1.15
IDH1 ENSG00000138413 2 2 1.15
STK4 ENSG00000101109 2 2 1.15
NUP107 ENSG00000111581 2 2 1.15
DDX3X ENSG00000215301 2 2 1.15
IRS2 ENSG00000185950 2 2 1.15
GOLGA5 ENSG00000066455 2 2 1.15
NTN4 ENSG00000074527 2 2 1.15
CDKN1A ENSG00000124762 2 2 1.15
RBM10 ENSG00000182872 2 2 1.15
ACO1 ENSG00000122729 2 2 1.15
PIK3R3 ENSG00000117461 2 2 1.15
THRAP3 ENSG00000054118 2 2 1.15
BLM ENSG00000197299 2 2 1.15
TNPO1 ENSG00000083312 2 2 1.15
SF3A3 ENSG00000183431 2 2 1.15
ACSL6 ENSG00000164398 2 2 1.15
TJP2 ENSG00000119139 2 2 1.15
PHF6 ENSG00000156531 2 2 1.15
ACVR1B ENSG00000135503 2 2 1.15
EEF1A1 ENSG00000156508 2 2 1.15
KRAS ENSG00000133703 2 2 1.15
ACAD8 ENSG00000151498 2 2 1.15
ARNTL ENSG00000133794 2 2 1.15