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169 mutational cancer drivers have been detected in this of Lung adenocarcinoma (LUAD) project from The Cancer Genome Atlas. The most mutated drivers are: TP53, KRAS, MLL3, NF1, KEAP1, etc.



Lung adenocarcinoma TCGA
LUAD Lung adenocarcinoma
228 Samples
Driver / Mut. genes169 / 22638
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 1317
in all genes 111328
Protein affecting mutations (PAMs)
in driver genes 1145
in all genes 60403
This driver cloud represents the most recurrently mutated cancer driver genes in the Lung adenocarcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Lung adenocarcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 120 120 52.63
KRAS ENSG00000133703 61 60 26.32
MLL3 ENSG00000055609 45 42 18.42
NF1 ENSG00000196712 36 27 11.84
KEAP1 ENSG00000079999 40 40 17.54
SVEP1 ENSG00000165124 31 29 12.72
FAT1 ENSG00000083857 31 30 13.16
KDR ENSG00000128052 24 23 10.09
LPHN2 ENSG00000117114 26 21 9.21
SETD2 ENSG00000181555 19 18 7.89
MGA ENSG00000174197 19 17 7.46
STK11 ENSG00000118046 20 20 8.77
SMARCA4 ENSG00000127616 18 17 7.46
BRAF ENSG00000157764 18 17 7.46
ARID1A ENSG00000117713 14 14 6.14
BAZ2B ENSG00000123636 10 10 4.39
CDKN2A ENSG00000147889 15 15 6.58
MMP2 ENSG00000087245 13 12 5.26
FN1 ENSG00000115414 14 13 5.70
RB1 ENSG00000139687 14 12 5.26
RBM10 ENSG00000182872 14 12 5.26
DNMT3A ENSG00000119772 9 9 3.95
EPHB2 ENSG00000133216 6 6 2.63
G3BP1 ENSG00000145907 8 8 3.51
EPHA4 ENSG00000116106 7 7 3.07
NTRK2 ENSG00000148053 7 7 3.07
CUL3 ENSG00000036257 6 6 2.63
CRNKL1 ENSG00000101343 6 5 2.19
U2AF1 ENSG00000160201 6 6 2.63
SPRR3 ENSG00000163209 6 2 0.88
EFTUD2 ENSG00000108883 5 5 2.19
NTN4 ENSG00000074527 5 5 2.19
PSMD11 ENSG00000108671 5 5 2.19
ACVR1B ENSG00000135503 5 5 2.19
SETDB1 ENSG00000143379 10 5 2.19
TAOK2 ENSG00000149930 9 5 2.19
POLR2B ENSG00000047315 8 4 1.75
CLASP2 ENSG00000163539 7 5 2.19
MLH1 ENSG00000076242 8 4 1.75
PAX5 ENSG00000196092 6 5 2.19
DDX5 ENSG00000108654 8 3 1.32
ZNF814 ENSG00000204514 6 3 1.32
PRPF8 ENSG00000174231 8 3 1.32
STIP1 ENSG00000168439 6 5 2.19
BAP1 ENSG00000163930 6 3 1.32
NUP107 ENSG00000111581 7 5 2.19
ACTG2 ENSG00000163017 7 5 2.19
NUP98 ENSG00000110713 7 6 2.63
TBL1XR1 ENSG00000177565 5 5 2.19
TCF4 ENSG00000196628 6 5 2.19
EZH2 ENSG00000106462 6 5 2.19
CREBBP ENSG00000005339 6 4 1.75
NRAS ENSG00000213281 6 4 1.75
BLM ENSG00000197299 6 6 2.63
CTCF ENSG00000102974 5 3 1.32
NFE2L2 ENSG00000116044 6 4 1.75
CNOT3 ENSG00000088038 6 3 1.32
HSP90AB1 ENSG00000096384 6 2 0.88
PTGS1 ENSG00000095303 6 4 1.75
SF3B1 ENSG00000115524 6 5 2.19
EIF2AK3 ENSG00000172071 5 5 2.19
RASA1 ENSG00000145715 5 3 1.32
PBRM1 ENSG00000163939 5 4 1.75
EEF1B2 ENSG00000114942 4 4 1.75
BRWD1 ENSG00000185658 5 5 2.19
CCT5 ENSG00000150753 2 2 0.88
CIC ENSG00000079432 5 4 1.75
ACO1 ENSG00000122729 5 4 1.75
CLSPN ENSG00000092853 5 4 1.75
CHD1L ENSG00000131778 4 3 1.32
COL1A1 ENSG00000108821 5 5 2.19
LDHA ENSG00000134333 5 3 1.32
PIP5K1A ENSG00000143398 5 5 2.19
CUL2 ENSG00000108094 4 4 1.75
SMC1A ENSG00000072501 5 3 1.32
PTEN ENSG00000171862 5 5 2.19
MAP2K1 ENSG00000169032 5 5 2.19
CYLD ENSG00000083799 5 4 1.75
PCSK6 ENSG00000140479 5 5 2.19
CNOT4 ENSG00000080802 5 5 2.19
TAOK1 ENSG00000160551 4 2 0.88
MAX ENSG00000125952 4 2 0.88
MAP3K1 ENSG00000095015 4 4 1.75
LCP1 ENSG00000136167 4 4 1.75
RHEB ENSG00000106615 4 4 1.75
ERBB2IP ENSG00000112851 4 4 1.75
STK4 ENSG00000101109 4 4 1.75
KDM6A ENSG00000147050 4 2 0.88
ACTG1 ENSG00000184009 4 3 1.32
MAP4K3 ENSG00000011566 4 3 1.32
FBXW7 ENSG00000109670 4 3 1.32
CAPN7 ENSG00000131375 4 4 1.75
HSP90AA1 ENSG00000080824 3 3 1.32
KLF6 ENSG00000067082 4 4 1.75
GNG2 ENSG00000186469 4 4 1.75
DHX15 ENSG00000109606 4 3 1.32
SIN3A ENSG00000169375 4 4 1.75
UPF3B ENSG00000125351 4 4 1.75
MKL1 ENSG00000196588 3 2 0.88
PPP2R1A ENSG00000105568 4 3 1.32
CDKN1B ENSG00000111276 4 4 1.75
COPS2 ENSG00000166200 4 4 1.75
TNPO1 ENSG00000083312 4 3 1.32
MYB ENSG00000118513 4 2 0.88
PHF6 ENSG00000156531 3 2 0.88
EIF4A2 ENSG00000156976 4 4 1.75
TP53BP1 ENSG00000067369 4 4 1.75
FUBP1 ENSG00000162613 4 3 1.32
MED24 ENSG00000008838 4 2 0.88
ARFGAP1 ENSG00000101199 4 4 1.75
STAG1 ENSG00000118007 4 2 0.88
FMR1 ENSG00000102081 4 4 1.75
ARHGAP26 ENSG00000145819 4 2 0.88
CASP8 ENSG00000064012 3 3 1.32
RBM5 ENSG00000003756 2 2 0.88
MEN1 ENSG00000133895 3 2 0.88
TOM1 ENSG00000100284 3 3 1.32
PSMA6 ENSG00000100902 2 2 0.88
SMAD2 ENSG00000175387 3 2 0.88
HLA-A ENSG00000206503 3 2 0.88
ATIC ENSG00000138363 3 3 1.32
PPP2R5A ENSG00000066027 3 3 1.32
IDH1 ENSG00000138413 2 2 0.88
PIK3R1 ENSG00000145675 3 3 1.32
HSPA8 ENSG00000109971 3 3 1.32
DDX3X ENSG00000215301 3 3 1.32
IRS2 ENSG00000185950 3 2 0.88
NEDD4L ENSG00000049759 3 3 1.32
GNAI1 ENSG00000127955 3 3 1.32
TFDP1 ENSG00000198176 3 3 1.32
RTN4 ENSG00000115310 2 2 0.88
MED17 ENSG00000042429 3 3 1.32
CARM1 ENSG00000142453 3 3 1.32
PRRX1 ENSG00000116132 3 2 0.88
MSR1 ENSG00000038945 3 3 1.32
SOX9 ENSG00000125398 3 3 1.32
CAT ENSG00000121691 3 3 1.32
FXR1 ENSG00000114416 3 2 0.88
ADAM10 ENSG00000137845 3 3 1.32
CCAR1 ENSG00000060339 3 3 1.32
MAP2K4 ENSG00000065559 3 3 1.32
EP300 ENSG00000100393 3 2 0.88
EIF2C3 ENSG00000126070 3 3 1.32
CSNK1G3 ENSG00000151292 3 3 1.32
ERCC2 ENSG00000104884 3 3 1.32
SYNCRIP ENSG00000135316 3 3 1.32
NCKAP1 ENSG00000061676 3 3 1.32
AFF4 ENSG00000072364 3 3 1.32
CDH1 ENSG00000039068 3 3 1.32
SHMT1 ENSG00000176974 3 2 0.88
TCF12 ENSG00000140262 3 3 1.32
ACAD8 ENSG00000151498 3 3 1.32
MYH10 ENSG00000133026 3 3 1.32
NPM1 ENSG00000181163 3 2 0.88
GPSM2 ENSG00000121957 2 2 0.88
TCF7L2 ENSG00000148737 2 2 0.88
IREB2 ENSG00000136381 2 2 0.88
BMPR2 ENSG00000204217 2 2 0.88
ATP6AP2 ENSG00000182220 2 2 0.88
TGFBR2 ENSG00000163513 2 2 0.88
CHEK2 ENSG00000183765 2 2 0.88
NF2 ENSG00000186575 2 2 0.88
RAD23B ENSG00000119318 2 2 0.88
G3BP2 ENSG00000138757 2 2 0.88
SFPQ ENSG00000116560 2 2 0.88
PIK3R3 ENSG00000117461 2 2 0.88
ZMYM2 ENSG00000121741 2 2 0.88
NCK1 ENSG00000158092 2 2 0.88
ACVR2A ENSG00000121989 2 2 0.88