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50 mutational cancer drivers have been detected in this of Lower grade glioma (LGG) project from The Cancer Genome Atlas. The most mutated drivers are: IDH1, TP53, ATRX, CIC, NOTCH1, etc.



Low Grade Glioma TCGA
LGG Lower grade glioma
169 Samples
Driver / Mut. genes50 / 7585
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 595
in all genes 11911
Protein affecting mutations (PAMs)
in driver genes 566
in all genes 5986
This driver cloud represents the most recurrently mutated cancer driver genes in the Low Grade Glioma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Low Grade Glioma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
IDH1 ENSG00000138413 131 131 77.51
TP53 ENSG00000141510 87 86 50.89
ATRX ENSG00000085224 72 72 42.60
CIC ENSG00000079432 35 34 20.12
NOTCH1 ENSG00000148400 16 13 7.69
FUBP1 ENSG00000162613 18 18 10.65
NF1 ENSG00000196712 11 10 5.92
PIK3CA ENSG00000121879 14 11 6.51
PIK3R1 ENSG00000145675 11 10 5.92
ARID1A ENSG00000117713 10 10 5.92
SMARCA4 ENSG00000127616 9 6 3.55
EGFR ENSG00000146648 7 7 4.14
ZNF292 ENSG00000188994 7 7 4.14
PTEN ENSG00000171862 7 7 4.14
IDH2 ENSG00000182054 6 6 3.55
TCF12 ENSG00000140262 6 6 3.55
SETD2 ENSG00000181555 4 4 2.37
ARID1B ENSG00000049618 4 4 2.37
MAX ENSG00000125952 3 3 1.78
KAT6B ENSG00000156650 3 3 1.78
TAF1 ENSG00000147133 4 3 1.78
MLL ENSG00000118058 4 3 1.78
CAD ENSG00000084774 4 2 1.18
MLL2 ENSG00000167548 4 2 1.18
NCOR1 ENSG00000141027 4 3 1.78
MECOM ENSG00000085276 3 3 1.78
RB1 ENSG00000139687 3 3 1.78
PTPN11 ENSG00000179295 3 3 1.78
HGF ENSG00000019991 3 3 1.78
CHEK2 ENSG00000183765 3 3 1.78
CDK12 ENSG00000167258 3 3 1.78
FAT1 ENSG00000083857 3 2 1.18
FAM123B ENSG00000184675 3 2 1.18
RASA1 ENSG00000145715 2 2 1.18
EEF1B2 ENSG00000114942 2 2 1.18
EIF1AX ENSG00000173674 2 2 1.18
DDX3X ENSG00000215301 2 2 1.18
TRIO ENSG00000038382 2 2 1.18
NEDD4L ENSG00000049759 2 2 1.18
NF2 ENSG00000186575 2 2 1.18
MTOR ENSG00000198793 2 2 1.18
TJP1 ENSG00000104067 2 2 1.18
ACO1 ENSG00000122729 2 2 1.18
ARFGEF2 ENSG00000124198 2 2 1.18
ZNF814 ENSG00000204514 2 2 1.18
MET ENSG00000105976 2 2 1.18
ZMYM2 ENSG00000121741 2 2 1.18
ARID2 ENSG00000189079 2 2 1.18
ARHGEF6 ENSG00000129675 2 2 1.18
ARHGAP26 ENSG00000145819 2 2 1.18