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131 mutational cancer drivers have been detected in this of Head and neck squamous cell carcinoma (HNSC) project from The Cancer Genome Atlas. The most mutated drivers are: TP53, FAT1, NOTCH1, CDKN2A, PIK3CA, etc.



Head and neck squamous cell carcinoma TCGA
HNSC Head and neck squamous cell carcinoma
301 Samples
Driver / Mut. genes131 / 21145
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 1512
in all genes 77072
Protein affecting mutations (PAMs)
in driver genes 1326
in all genes 38820
This driver cloud represents the most recurrently mutated cancer driver genes in the Head and neck squamous cell carcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Head and neck squamous cell carcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 212 208 69.10
FAT1 ENSG00000083857 73 72 23.92
NOTCH1 ENSG00000148400 61 56 18.60
CDKN2A ENSG00000147889 64 62 20.60
PIK3CA ENSG00000121879 62 61 20.27
MLL2 ENSG00000167548 54 53 17.61
NSD1 ENSG00000165671 32 32 10.63
LAMA2 ENSG00000196569 31 28 9.30
MACF1 ENSG00000127603 28 23 7.64
CASP8 ENSG00000064012 27 25 8.31
EP300 ENSG00000100393 24 23 7.64
FAT2 ENSG00000086570 23 20 6.64
KALRN ENSG00000160145 23 21 6.98
MLL ENSG00000118058 12 12 3.99
FBXW7 ENSG00000109670 16 14 4.65
NFE2L2 ENSG00000116044 16 16 5.32
NOTCH2 ENSG00000134250 15 13 4.32
EPHA2 ENSG00000142627 13 12 3.99
MYH9 ENSG00000100345 15 12 3.99
ZNF750 ENSG00000141579 12 11 3.65
SMARCA4 ENSG00000127616 12 12 3.99
WHSC1 ENSG00000109685 12 10 3.32
SPTAN1 ENSG00000197694 13 11 3.65
NCOR1 ENSG00000141027 12 10 3.32
RASA1 ENSG00000145715 13 11 3.65
RPSAP58 ENSG00000205246 13 13 4.32
HLA-A ENSG00000206503 12 9 2.99
CTCF ENSG00000102974 10 10 3.32
ARID2 ENSG00000189079 10 10 3.32
CUL3 ENSG00000036257 10 10 3.32
TGFBR2 ENSG00000163513 10 8 2.66
TAOK2 ENSG00000149930 10 8 2.66
ARHGAP35 ENSG00000160007 11 11 3.65
HRAS ENSG00000174775 10 10 3.32
MEF2C ENSG00000081189 9 8 2.66
RAC1 ENSG00000136238 8 8 2.66
KDM6A ENSG00000147050 8 8 2.66
HLA-B ENSG00000234745 7 7 2.33
CUL1 ENSG00000055130 6 6 1.99
CIITA ENSG00000179583 7 5 1.66
CSNK2A1 ENSG00000101266 6 6 1.99
APAF1 ENSG00000120868 7 7 2.33
B2M ENSG00000166710 7 4 1.33
PSIP1 ENSG00000164985 7 7 2.33
CYLD ENSG00000083799 7 7 2.33
MGMT ENSG00000170430 7 5 1.66
TRIP10 ENSG00000125733 6 5 1.66
BCL11A ENSG00000119866 6 5 1.66
PABPC3 ENSG00000151846 5 5 1.66
PAX5 ENSG00000196092 5 5 1.66
RASGRP1 ENSG00000172575 5 5 1.66
ELF4 ENSG00000102034 5 5 1.66
FUBP1 ENSG00000162613 5 5 1.66
MUC20 ENSG00000176945 13 2 0.66
STAG2 ENSG00000101972 16 2 0.66
CARM1 ENSG00000142453 8 3 1.00
POLR2B ENSG00000047315 6 3 1.00
CCAR1 ENSG00000060339 6 3 1.00
NCKAP1 ENSG00000061676 5 3 1.00
CDH1 ENSG00000039068 6 3 1.00
SF3B1 ENSG00000115524 6 2 0.66
CTNNB1 ENSG00000168036 4 2 0.66
MAP3K1 ENSG00000095015 5 3 1.00
IREB2 ENSG00000136381 4 3 1.00
CAD ENSG00000084774 5 2 0.66
CEP290 ENSG00000198707 5 3 1.00
NCF2 ENSG00000116701 5 4 1.33
MGA ENSG00000174197 5 3 1.00
CLSPN ENSG00000092853 3 3 1.00
PPP2R1A ENSG00000105568 5 3 1.00
BAP1 ENSG00000163930 4 3 1.00
BRAF ENSG00000157764 4 3 1.00
BMPR2 ENSG00000204217 4 3 1.00
RUNX1 ENSG00000159216 3 2 0.66
U2AF1 ENSG00000160201 4 3 1.00
BRWD1 ENSG00000185658 4 3 1.00
HSPA8 ENSG00000109971 4 2 0.66
FLT3 ENSG00000122025 4 2 0.66
PRRX1 ENSG00000116132 4 2 0.66
SOX9 ENSG00000125398 4 2 0.66
ADAM10 ENSG00000137845 3 2 0.66
SPOP ENSG00000121067 4 3 1.00
CASP1 ENSG00000137752 4 2 0.66
TJP2 ENSG00000119139 3 3 1.00
SMC1A ENSG00000072501 4 3 1.00
ARHGEF6 ENSG00000129675 4 3 1.00
TAOK1 ENSG00000160551 3 2 0.66
GPSM2 ENSG00000121957 3 2 0.66
STIP1 ENSG00000168439 3 2 0.66
TBL1XR1 ENSG00000177565 3 3 1.00
SMAD2 ENSG00000175387 3 3 1.00
ELF1 ENSG00000120690 3 3 1.00
TBX3 ENSG00000135111 3 2 0.66
TFDP1 ENSG00000198176 3 3 1.00
CCT5 ENSG00000150753 3 2 0.66
MSR1 ENSG00000038945 3 3 1.00
ZC3H11A ENSG00000058673 3 3 1.00
KLF6 ENSG00000067082 3 2 0.66
SIN3A ENSG00000169375 3 2 0.66
CDKN1B ENSG00000111276 3 2 0.66
PIK3R3 ENSG00000117461 3 3 1.00
THRAP3 ENSG00000054118 3 3 1.00
AKT1 ENSG00000142208 3 2 0.66
KDM5C ENSG00000126012 3 3 1.00
EEF1A1 ENSG00000156508 3 2 0.66
RAD21 ENSG00000164754 3 3 1.00
AHR ENSG00000106546 3 3 1.00
ARFGAP1 ENSG00000101199 3 3 1.00
SEC24D ENSG00000150961 3 2 0.66
ACAD8 ENSG00000151498 3 3 1.00
NFATC4 ENSG00000100968 2 2 0.66
MEN1 ENSG00000133895 2 2 0.66
HNRPDL ENSG00000152795 2 2 0.66
TCF4 ENSG00000196628 2 2 0.66
ATIC ENSG00000138363 2 2 0.66
ATP6AP2 ENSG00000182220 2 2 0.66
NUP107 ENSG00000111581 2 2 0.66
IRS2 ENSG00000185950 2 2 0.66
NEDD4L ENSG00000049759 2 2 0.66
ACTG1 ENSG00000184009 2 2 0.66
MED17 ENSG00000042429 2 2 0.66
ACTB ENSG00000075624 2 2 0.66
FGFR2 ENSG00000066468 2 2 0.66
RPL22 ENSG00000116251 2 2 0.66
PPP2R5C ENSG00000078304 2 2 0.66
CAT ENSG00000121691 2 2 0.66
NR4A2 ENSG00000153234 2 2 0.66
FMR1 ENSG00000102081 2 2 0.66
TCF12 ENSG00000140262 2 2 0.66
CNOT4 ENSG00000080802 2 2 0.66
ACVR2A ENSG00000121989 2 2 0.66