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7 mutational cancer drivers have been detected in this of Glioblastoma multiforme (GBM) project from Johns Hopkins University. The most mutated drivers are: TP53, PTEN, NF1, EGFR, IDH1, etc.



Glioblastoma multiforme Johns Hopkins University
GBM Glioblastoma multiforme
89 Samples
Driver / Mut. genes7 / 2961
Johns Hopkins University
PMID:18772396
Coding sequence mutations (CSMs)
in driver genes 125
in all genes 3612
Protein affecting mutations (PAMs)
in driver genes 121
in all genes 1704
This driver cloud represents the most recurrently mutated cancer driver genes in the Glioblastoma multiforme Johns Hopkins University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Glioblastoma multiforme Johns Hopkins University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 35 35 39.33
PTEN ENSG00000171862 27 26 29.21
NF1 ENSG00000196712 17 16 17.98
EGFR ENSG00000146648 15 14 15.73
IDH1 ENSG00000138413 12 12 13.48
RB1 ENSG00000139687 8 8 8.99
HDAC9 ENSG00000048052 2 2 2.25