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98 mutational cancer drivers have been detected in this of Esophageal carcinoma (ESCA) project from Dana Farber Cancer Institute. The most mutated drivers are: TP53, CDKN2A, SMAD4, ARID1A, SMARCA4, etc.



Esophagea cancer Dana Farber Cancer Institute obtained from AlexandrovEtAl
ESCA Esophageal carcinoma
146 Samples
Driver / Mut. genes98 / 16972
Dana Farber Cancer Institute
doi:10.1038/ng.2591
Coding sequence mutations (CSMs)
in driver genes 455
in all genes 40925
Protein affecting mutations (PAMs)
in driver genes 368
in all genes 17832
This driver cloud represents the most recurrently mutated cancer driver genes in the Esophagea cancer Dana Farber Cancer Institute obtained from AlexandrovEtAl dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Esophagea cancer Dana Farber Cancer Institute obtained from AlexandrovEtAl dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 75 74 50.68
CDKN2A ENSG00000147889 18 15 10.27
SMAD4 ENSG00000141646 13 12 8.22
ARID1A ENSG00000117713 12 11 7.53
SMARCA4 ENSG00000127616 11 9 6.16
ARID2 ENSG00000189079 8 8 5.48
PIK3CA ENSG00000121879 9 7 4.79
ASPM ENSG00000066279 7 7 4.79
CLTC ENSG00000141367 6 3 2.05
MTOR ENSG00000198793 5 3 2.05
MACF1 ENSG00000127603 6 3 2.05
ATM ENSG00000149311 7 3 2.05
BAP1 ENSG00000163930 6 3 2.05
MLL2 ENSG00000167548 5 3 2.05
CNOT1 ENSG00000125107 5 3 2.05
CREBBP ENSG00000005339 5 3 2.05
SPTAN1 ENSG00000197694 5 3 2.05
MGA ENSG00000174197 5 2 1.37
ACSL6 ENSG00000164398 5 3 2.05
PTPRU ENSG00000060656 4 2 1.37
NUP98 ENSG00000110713 5 2 1.37
EGFR ENSG00000146648 5 3 2.05
RHOA ENSG00000067560 4 2 1.37
NSD1 ENSG00000165671 3 2 1.37
TRIO ENSG00000038382 4 3 2.05
CEP290 ENSG00000198707 4 3 2.05
TAOK2 ENSG00000149930 4 2 1.37
DDX5 ENSG00000108654 4 3 2.05
MSR1 ENSG00000038945 4 2 1.37
ATR ENSG00000175054 4 3 2.05
KALRN ENSG00000160145 4 3 2.05
CIC ENSG00000079432 4 3 2.05
ATRX ENSG00000085224 4 2 1.37
LRP6 ENSG00000070018 4 3 2.05
CNOT3 ENSG00000088038 4 2 1.37
AHR ENSG00000106546 4 3 2.05
TAOK1 ENSG00000160551 3 3 2.05
CTNNB1 ENSG00000168036 3 3 2.05
IREB2 ENSG00000136381 3 2 1.37
DLG1 ENSG00000075711 3 3 2.05
EZH2 ENSG00000106462 3 3 2.05
ERBB2IP ENSG00000112851 3 2 1.37
MAP3K4 ENSG00000085511 3 3 2.05
NUP107 ENSG00000111581 3 2 1.37
SETD2 ENSG00000181555 3 3 2.05
FLT3 ENSG00000122025 3 2 1.37
ITSN1 ENSG00000205726 3 2 1.37
RTN4 ENSG00000115310 3 2 1.37
FBXW7 ENSG00000109670 3 2 1.37
FGFR2 ENSG00000066468 3 2 1.37
SRGAP3 ENSG00000196220 3 2 1.37
CAPN7 ENSG00000131375 3 2 1.37
ELF3 ENSG00000163435 3 2 1.37
BPTF ENSG00000171634 3 2 1.37
ARHGAP35 ENSG00000160007 3 2 1.37
SOX9 ENSG00000125398 3 2 1.37
RBM10 ENSG00000182872 3 2 1.37
ZFP36L2 ENSG00000152518 3 3 2.05
EP300 ENSG00000100393 3 3 2.05
ARFGEF2 ENSG00000124198 3 3 2.05
CDKN1B ENSG00000111276 3 3 2.05
ZNF814 ENSG00000204514 3 2 1.37
CHD4 ENSG00000111642 3 2 1.37
EIF4G1 ENSG00000114867 3 2 1.37
SYNCRIP ENSG00000135316 3 3 2.05
BCLAF1 ENSG00000029363 3 3 2.05
AFF4 ENSG00000072364 3 3 2.05
RAD21 ENSG00000164754 3 2 1.37
CDH1 ENSG00000039068 3 3 2.05
TAF1 ENSG00000147133 2 2 1.37
CUL3 ENSG00000036257 2 2 1.37
EIF2AK3 ENSG00000172071 2 2 1.37
TBX3 ENSG00000135111 2 2 1.37
KDM6A ENSG00000147050 2 2 1.37
IRS2 ENSG00000185950 2 2 1.37
HGF ENSG00000019991 2 2 1.37
PAX5 ENSG00000196092 2 2 1.37
HLA-B ENSG00000234745 2 2 1.37
ZC3H11A ENSG00000058673 2 2 1.37
ADAM10 ENSG00000137845 2 2 1.37
MAP2K4 ENSG00000065559 2 2 1.37
ACO1 ENSG00000122729 2 2 1.37
CSNK1G3 ENSG00000151292 2 2 1.37
BLM ENSG00000197299 2 2 1.37
MET ENSG00000105976 2 2 1.37
ERCC2 ENSG00000104884 2 2 1.37
NFE2L2 ENSG00000116044 2 2 1.37
TP53BP1 ENSG00000067369 2 2 1.37
SMC1A ENSG00000072501 2 2 1.37
NCKAP1 ENSG00000061676 2 2 1.37
ACVR1B ENSG00000135503 2 2 1.37
EEF1A1 ENSG00000156508 2 2 1.37
WT1 ENSG00000184937 2 2 1.37
SHMT1 ENSG00000176974 2 2 1.37
ARHGAP26 ENSG00000145819 2 2 1.37
ARNTL ENSG00000133794 2 2 1.37
MED12 ENSG00000184634 2 2 1.37
SF3B1 ENSG00000115524 2 2 1.37