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89 mutational cancer drivers have been detected in this of Colorectal adenocarcinoma (COREAD) project from The Cancer Genome Atlas. The most mutated drivers are: APC, TP53, KRAS, PIK3CA, FBXW7, etc.



Colorectal adenocarcinoma TCGA
COREAD Colorectal adenocarcinoma
193 Samples
Driver / Mut. genes89 / 13009
The Cancer Genome Atlas
doi:10.1038/nature11252
Coding sequence mutations (CSMs)
in driver genes 862
in all genes 28189
Protein affecting mutations (PAMs)
in driver genes 813
in all genes 15124
This driver cloud represents the most recurrently mutated cancer driver genes in the Colorectal adenocarcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Colorectal adenocarcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
APC ENSG00000134982 158 158 81.87
TP53 ENSG00000141510 115 114 59.07
KRAS ENSG00000133703 87 87 45.08
PIK3CA ENSG00000121879 34 34 17.62
FBXW7 ENSG00000109670 23 21 10.88
SMAD4 ENSG00000141646 19 18 9.33
TCF7L2 ENSG00000148737 18 18 9.33
NRAS ENSG00000213281 17 17 8.81
FAM123B ENSG00000184675 15 15 7.77
ARID1A ENSG00000117713 12 11 5.70
ATM ENSG00000149311 11 11 5.70
SMAD2 ENSG00000175387 11 11 5.70
CTNNB1 ENSG00000168036 9 9 4.66
SOX9 ENSG00000125398 8 8 4.15
CHD4 ENSG00000111642 9 8 4.15
AXIN2 ENSG00000168646 7 7 3.63
ACVR1B ENSG00000135503 7 7 3.63
BRAF ENSG00000157764 7 7 3.63
ELF3 ENSG00000163435 7 7 3.63
RBM10 ENSG00000182872 6 5 2.59
PCBP1 ENSG00000169564 5 5 2.59
STAG2 ENSG00000101972 9 2 1.04
CREBBP ENSG00000005339 5 4 2.07
DIS3 ENSG00000083520 5 3 1.55
MLL2 ENSG00000167548 5 3 1.55
MED12 ENSG00000184634 5 3 1.55
MAP3K4 ENSG00000085511 4 3 1.55
PIK3R1 ENSG00000145675 4 3 1.55
BRWD1 ENSG00000185658 4 3 1.55
CEP290 ENSG00000198707 4 2 1.04
ASPM ENSG00000066279 4 3 1.55
SOS2 ENSG00000100485 3 3 1.55
CLSPN ENSG00000092853 4 3 1.55
PPP2R1A ENSG00000105568 4 3 1.55
MED24 ENSG00000008838 4 3 1.55
CNOT1 ENSG00000125107 4 3 1.55
WT1 ENSG00000184937 4 2 1.04
EGFR ENSG00000146648 4 3 1.55
CHD9 ENSG00000177200 4 3 1.55
TAF1 ENSG00000147133 3 3 1.55
MECOM ENSG00000085276 3 2 1.04
BCOR ENSG00000183337 3 3 1.55
TRIO ENSG00000038382 3 3 1.55
ITSN1 ENSG00000205726 3 2 1.04
GOLGA5 ENSG00000066455 3 3 1.55
NTN4 ENSG00000074527 3 3 1.55
SRGAP3 ENSG00000196220 3 3 1.55
CDC73 ENSG00000134371 3 3 1.55
MSR1 ENSG00000038945 3 2 1.04
BPTF ENSG00000171634 3 2 1.04
FOXP1 ENSG00000114861 3 3 1.55
NF1 ENSG00000196712 3 2 1.04
IDH2 ENSG00000182054 3 3 1.55
MGA ENSG00000174197 3 3 1.55
ACO1 ENSG00000122729 3 2 1.04
CTCF ENSG00000102974 3 3 1.55
CDK12 ENSG00000167258 3 3 1.55
SMC1A ENSG00000072501 3 3 1.55
NR2F2 ENSG00000185551 3 2 1.04
LPHN2 ENSG00000117114 3 3 1.55
NUP98 ENSG00000110713 3 2 1.04
PTEN ENSG00000171862 3 2 1.04
ARNTL ENSG00000133794 3 2 1.04
MYH10 ENSG00000133026 3 2 1.04
CASP8 ENSG00000064012 3 3 1.55
POLR2B ENSG00000047315 2 2 1.04
BMPR2 ENSG00000204217 2 2 1.04
RUNX1 ENSG00000159216 2 2 1.04
CUL1 ENSG00000055130 2 2 1.04
TBX3 ENSG00000135111 2 2 1.04
PTPN11 ENSG00000179295 2 2 1.04
NUP107 ENSG00000111581 2 2 1.04
RTN4 ENSG00000115310 2 2 1.04
ZC3H11A ENSG00000058673 2 2 1.04
DNMT3A ENSG00000119772 2 2 1.04
FXR1 ENSG00000114416 2 2 1.04
ATRX ENSG00000085224 2 2 1.04
CDKN1B ENSG00000111276 2 2 1.04
WIPF1 ENSG00000115935 2 2 1.04
NR4A2 ENSG00000153234 2 2 1.04
GATA3 ENSG00000107485 2 2 1.04
SYNCRIP ENSG00000135316 2 2 1.04
ACSL6 ENSG00000164398 2 2 1.04
TP53BP1 ENSG00000067369 2 2 1.04
RAD21 ENSG00000164754 2 2 1.04
PTGS1 ENSG00000095303 2 2 1.04
MAP2K1 ENSG00000169032 2 2 1.04
TCF12 ENSG00000140262 2 2 1.04
SF3B1 ENSG00000115524 2 2 1.04