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171 mutational cancer drivers have been detected in this of Cutaneous melanoma (CM) project from The Cancer Genome Atlas. The most mutated drivers are: ANK3, BRAF, SVEP1, PCDH18, NRAS, etc.



Skin cutaneous melanoma TCGA obtained from Synapse
CM Cutaneous melanoma
249 Samples
Driver / Mut. genes171 / 25555
The Cancer Genome Atlas
Coding sequence mutations (CSMs)
in driver genes 2432
in all genes 231442
Protein affecting mutations (PAMs)
in driver genes 1961
in all genes 110503
This driver cloud represents the most recurrently mutated cancer driver genes in the Skin cutaneous melanoma TCGA obtained from Synapse dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Skin cutaneous melanoma TCGA obtained from Synapse dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
ANK3 ENSG00000151150 100 79 31.73
BRAF ENSG00000157764 132 131 52.61
SVEP1 ENSG00000165124 61 49 19.68
PCDH18 ENSG00000189184 57 49 19.68
NRAS ENSG00000213281 72 70 28.11
MECOM ENSG00000085276 57 49 19.68
AHNAK ENSG00000124942 50 36 14.46
PLCB1 ENSG00000182621 40 34 13.65
MLL3 ENSG00000055609 49 44 17.67
NF1 ENSG00000196712 42 35 14.06
ARID2 ENSG00000189079 38 36 14.46
BCLAF1 ENSG00000029363 40 35 14.06
HDAC9 ENSG00000048052 33 26 10.44
COL1A1 ENSG00000108821 37 32 12.85
ASPM ENSG00000066279 32 28 11.24
TP53 ENSG00000141510 37 35 14.06
CDKN2A ENSG00000147889 33 32 12.85
CHD6 ENSG00000124177 30 26 10.44
C15orf55 ENSG00000184507 25 22 8.84
BLM ENSG00000197299 21 18 7.23
TRERF1 ENSG00000124496 22 20 8.03
BPTF ENSG00000171634 26 24 9.64
BAZ2B ENSG00000123636 26 22 8.84
MSR1 ENSG00000038945 20 18 7.23
PTEN ENSG00000171862 23 23 9.24
PPP6C ENSG00000119414 21 20 8.03
POM121 ENSG00000196313 19 13 5.22
EIF2AK3 ENSG00000172071 17 16 6.43
NCOR1 ENSG00000141027 20 16 6.43
NUP98 ENSG00000110713 20 14 5.62
ARHGEF2 ENSG00000116584 19 16 6.43
CHD9 ENSG00000177200 18 16 6.43
IRF7 ENSG00000185507 18 7 2.81
CLCC1 ENSG00000121940 18 15 6.02
DDX3X ENSG00000215301 18 18 7.23
LRPPRC ENSG00000138095 13 13 5.22
MAP2K1 ENSG00000169032 16 13 5.22
EZH2 ENSG00000106462 15 14 5.62
IDH1 ENSG00000138413 15 14 5.62
EIF4G3 ENSG00000075151 13 12 4.82
RAC1 ENSG00000136238 15 14 5.62
EIF4G1 ENSG00000114867 13 12 4.82
MAP3K4 ENSG00000085511 14 13 5.22
AHCTF1 ENSG00000153207 13 12 4.82
XRN1 ENSG00000114127 13 13 5.22
AQR ENSG00000021776 13 12 4.82
TAOK1 ENSG00000160551 12 11 4.42
CTNNB1 ENSG00000168036 12 11 4.42
STAG1 ENSG00000118007 12 11 4.42
SEC24D ENSG00000150961 12 10 4.02
RASA2 ENSG00000155903 11 11 4.42
MCM3 ENSG00000112118 9 8 3.21
CASP8 ENSG00000064012 9 8 3.21
ITGA9 ENSG00000144668 9 9 3.61
MCM8 ENSG00000125885 8 7 2.81
MFNG ENSG00000100060 8 8 3.21
FAF1 ENSG00000185104 7 7 2.81
COPS2 ENSG00000166200 7 6 2.41
ARHGEF6 ENSG00000129675 7 7 2.81
MED24 ENSG00000008838 11 3 1.20
RHOA ENSG00000067560 11 2 0.80
WT1 ENSG00000184937 9 5 2.01
BAP1 ENSG00000163930 9 4 1.61
PIK3R1 ENSG00000145675 8 5 2.01
CLSPN ENSG00000092853 8 5 2.01
STK11 ENSG00000118046 7 4 1.61
MEN1 ENSG00000133895 8 4 1.61
LCP1 ENSG00000136167 8 5 2.01
ACTG1 ENSG00000184009 8 5 2.01
DNMT3A ENSG00000119772 8 5 2.01
ACTG2 ENSG00000163017 8 4 1.61
CASP1 ENSG00000137752 8 3 1.20
PPP2R5A ENSG00000066027 7 5 2.01
CHEK2 ENSG00000183765 7 3 1.20
MLH1 ENSG00000076242 6 2 0.80
CCAR1 ENSG00000060339 7 5 2.01
NR4A2 ENSG00000153234 5 3 1.20
SYNCRIP ENSG00000135316 6 3 1.20
EIF4A2 ENSG00000156976 7 4 1.61
HRAS ENSG00000174775 6 4 1.61
SMAD2 ENSG00000175387 5 3 1.20
RPL5 ENSG00000122406 6 5 2.01
ATIC ENSG00000138363 6 6 2.41
TBX3 ENSG00000135111 6 4 1.61
HSPA8 ENSG00000109971 5 4 1.61
NF2 ENSG00000186575 6 5 2.01
DDX5 ENSG00000108654 6 3 1.20
DIS3 ENSG00000083520 6 5 2.01
ZC3H11A ENSG00000058673 5 4 1.61
KLF6 ENSG00000067082 6 4 1.61
B2M ENSG00000166710 6 5 2.01
DHX15 ENSG00000109606 6 3 1.20
AKT1 ENSG00000142208 6 3 1.20
TNPO1 ENSG00000083312 6 4 1.61
KDM5C ENSG00000126012 6 4 1.61
CDH1 ENSG00000039068 6 3 1.20
CYLD ENSG00000083799 6 5 2.01
KRAS ENSG00000133703 5 3 1.20
CUL3 ENSG00000036257 5 4 1.61
RASA1 ENSG00000145715 4 3 1.20
MAP3K1 ENSG00000095015 5 4 1.61
CAST ENSG00000153113 5 4 1.61
SMAD4 ENSG00000141646 5 2 0.80
HLA-A ENSG00000206503 5 2 0.80
PAX5 ENSG00000196092 5 4 1.61
HLA-B ENSG00000234745 5 4 1.61
CDKN1A ENSG00000124762 5 4 1.61
KLF4 ENSG00000136826 5 4 1.61
CDC73 ENSG00000134371 5 4 1.61
ELF3 ENSG00000163435 5 2 0.80
ZFP36L2 ENSG00000152518 5 5 2.01
ACO1 ENSG00000122729 5 4 1.61
PIK3R3 ENSG00000117461 5 2 0.80
LDHA ENSG00000134333 5 5 2.01
WIPF1 ENSG00000115935 5 4 1.61
CTCF ENSG00000102974 5 2 0.80
NFE2L2 ENSG00000116044 4 3 1.20
SF3A3 ENSG00000183431 5 5 2.01
PIP5K1A ENSG00000143398 5 4 1.61
ATF1 ENSG00000123268 5 5 2.01
CUL2 ENSG00000108094 5 4 1.61
VHL ENSG00000134086 5 4 1.61
FUBP1 ENSG00000162613 5 4 1.61
ACVR1B ENSG00000135503 5 2 0.80
RAD21 ENSG00000164754 5 4 1.61
AHR ENSG00000106546 5 4 1.61
FAS ENSG00000026103 5 5 2.01
TCF12 ENSG00000140262 5 5 2.01
ACVR2A ENSG00000121989 4 3 1.20
CLOCK ENSG00000134852 4 4 1.61
PSMA6 ENSG00000100902 4 4 1.61
KDM6A ENSG00000147050 4 4 1.61
TFDP1 ENSG00000198176 4 2 0.80
RTN4 ENSG00000115310 4 4 1.61
CCT5 ENSG00000150753 4 4 1.61
RPL22 ENSG00000116251 4 2 0.80
PPP2R5C ENSG00000078304 4 4 1.61
TFDP2 ENSG00000114126 4 4 1.61
GNG2 ENSG00000186469 4 3 1.20
FXR1 ENSG00000114416 4 4 1.61
MAP2K4 ENSG00000065559 4 4 1.61
CNOT3 ENSG00000088038 4 3 1.20
PHF6 ENSG00000156531 4 2 0.80
SMC1A ENSG00000072501 4 3 1.20
ZMYM2 ENSG00000121741 4 4 1.61
RHEB ENSG00000106615 3 2 0.80
GOLGA5 ENSG00000066455 3 2 0.80
MED17 ENSG00000042429 3 3 1.20
RAD23B ENSG00000119318 3 3 1.20
G3BP2 ENSG00000138757 3 2 0.80
SOX9 ENSG00000125398 3 2 0.80
SFPQ ENSG00000116560 3 3 1.20
SUZ12 ENSG00000178691 3 2 0.80
SPOP ENSG00000121067 3 2 0.80
CSNK1G3 ENSG00000151292 3 3 1.20
GATA3 ENSG00000107485 3 3 1.20
ARFGAP1 ENSG00000101199 3 3 1.20
YBX1 ENSG00000065978 3 3 1.20
FMR1 ENSG00000102081 3 2 0.80
CBFB ENSG00000067955 3 3 1.20
NPM1 ENSG00000181163 3 3 1.20
RBBP7 ENSG00000102054 2 2 0.80
HNRPDL ENSG00000152795 2 2 0.80
BMPR2 ENSG00000204217 2 2 0.80
EIF1AX ENSG00000173674 2 2 0.80
ATP6AP2 ENSG00000182220 2 2 0.80
CSDA ENSG00000060138 2 2 0.80
IDH2 ENSG00000182054 2 2 0.80
PPP2R1A ENSG00000105568 2 2 0.80
NR2F2 ENSG00000185551 2 2 0.80
HLF ENSG00000108924 2 2 0.80